6 TH INTERNATIONAL CONFERENCE ON THORACIC ONCOLOGY

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1 6 TH INTERNATIONAL CONFERENCE ON THORACIC ONCOLOGY Milan, June 21 st - 23 rd 2018 STARHOTELS ROSA GRANd piazza Fontana 3, milano programme

2 PRESIDENT OF THE CONFERENCE Filippo de Marinis SCIENTIFIC & ORGANIZING COMMITTEE AIOT Board Fortunato Ciardiello Filippo de Marinis Cesare Gridelli Lucio Crinò Marina Chiara Garassino Nicola Normanno Lorenzo Spaggiari

3 WELCOME FROM THE PRESIDENT Under the auspices of Dear Collegue, it s my great pleasure to invite you to partecipate in the proceedings of 6 th Italian Conference on Thoracic Oncology (CIOT) that, in its annual recurrence, will take place in Milan from June 21 st to June 23 rd 2018 organized by AIOT (Italian Association of Thoracic Oncology) and that I ve the responsibility to chair. I would like to call your attention to at least three interesting aspects of Milan s Conference that make the appointment very peculiar and that I identify in its International form, in the location and in its goals. International form The 70% of Faculty is composed of foreign speakers, everybody playing an active part in clinical research in Thoracic Oncology and KOL in their respective countries. We expect a significant foreign delegation. The official language of the Conference will be English. Goals Setted immediately after ASCO, the Conference will give an update on the data coming from Clinical Research in Thoracic Oncology directly from the voice of its Authors more representative in an appointment that we would like to be lasting inside of the international congressional track. For these reasons I m trusting that you should appreciate the effort of the organizing secretariat to realize this scientific meeting doing credit to us with your attendance in Milan. Arrivederci President of 6th CIOT Filippo de Marinis Location Located in a wonderful position, in the heart of Milan, the conference venue offers to the city a meeting point of extraordinary importance. Its natural elegance and flexibility make it the ideal location for congresses, meetings and events of any kind. The location is in the heart of history and Milan fashion district.

4 GENERAL INFORMATION CONFERENCE VENUE STARHOTELS ROSA GRAND piazza Fontana 3, milano Tel. (+39) The STARHOTELS ROSA GRAND is located in the center of the main cultural area of the city and about 500 metres from the famous shopping area. The meeting takes place in the Auditorium located at the ground floor of the Hotel. HOTEL ACCOMMODATION Organizing secretariat SOS Scientific Organizing Service S.r.l. will be at your disposal for any information on hotel reservations.

5 PRACTICAL INFORMATION PARKING FACILITIES The indoor car parking, located aside the Hotel, will be at disposal of all the delegates at their charge; SECRETARIAT AND REGISTRATION DESKS The pre-registration and on site registration desks will be at the disposal of participants as follow: Thursday, June /18.30 hrs Friday, June /18.30 hrs Saturday, June /13.00 hrs At the secretariat desk will be available the following services: On site registration (cash, cheques) Pre-registrations A - L Pre-registrations M - Z Faculty registration CME credits desk CLOAKROOM It will be at disposal of all the guests free of charge. Delegates are kindly requested not to leave their personal belongings after the closing time. BAR Located in the Conference area it will be at the disposal of the participants at their charge. CLIMATE June weather in Milan is generally sunny and warm. The temperature often rises during the day at an average of 25. Light summer clothing is most suitable. Rain is also possible; light raincoat and something warm for the evening are advisable CURRENCY The official currency in Italy is the Euro ( ). TIPPING Service is usually included in the bill in bars and restaurants but tips are welcome. BANK Banks are open from Monday to Friday from to hrs and from to hrs. Banks are closed on Saturday and Sunday. Many banks have automatic currency exchange machines that also take credit cards. Most hotels, restaurants and shops accept foreign currency and major credit cards. ELECTRICITY Voltage is 220V AC, 50Hz. Plugs have two or three round pins. Foreign voltage could require and adapter. INSURANCE Conference organizers cannot accept liability for personal injuries or for loss of or damage to property belonging to congress participants, either during or as a result of the Conference.

6 REGISTRATION FEES All fees are requested in Euros. It s possible to register individually by visiting AIOT website in the proper section following the instructions.. WHAT IS COVERED BY THE FEE? The registration fee includes an unlimited access to all scientific sessions, a full set of congress material and lunch on Friday June 22. ADMISSION Name badges will be used as passes. All participants and official guests are kindly requested to wear their name badge during the Meeting activities and social events. The badge will allow the entrance to the scientific sessions and lunch.

7 MILAN KEY ATTRACTIONS

8 MILAN KEY ATTRACTIONS 1 1. Duomo 4. Santa Maria delle Grazie 2. Palazzo Reale 5. Navigli 3. Castello Sforzesco 6. Via Monte Napoleone 7. Piazza Gae Aulenti 8. Citylife

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10 SCIENTIFIC INFORMATION MAIN SCIENTIFIC PROGRAMME OUTLINE The scientific programme covers three days (Thursday June 21, Friday June 22 and Saturday June 23, 2018) and consists of State-of-the-Art Lectures, Main Lectures, Debates and Face to Face sessions. The Debates sessions will be about controversial topics in thoracic oncology; the Face to Face sessions instead will go on vexed questions and they will deal with two speakers and to add requests from some shooters put in charge in order to stimulate the audience for a lively discussion. WEBSITE Virtual Meeting of the Conference will be available after the end of the Meeting on AIOT official website ITALIAN MINISTRY OF HEALTH - CME CREDITS The accreditation has been asked for entirely meeting. To obtain Italian credits the delegates must attend in the 100% percentage of the time sessions. An electronic device will be arrange. At the moment of registration each participant will receive the evaluation forms and learning questionnaire of the scientific sessions. These forms and questionnaire must be filled in and return to the CME credits desk. Electronic tags will be used to record the CME credits. The electronic readers will be placed just outside the Auditorium. It will be sufficient to pass through the electronic device to have the credits recorded. To obtain credits, Italian participants must be: record both the entrance and the exit of each Meeting day return the electronic tag to the Organizing Secretariat at the end of the Conference return the evaluation forms and questionnaire duly filled into the CME credits desk. The anagraphical data must compulsorily be indicated since required by the Italian Ministry of Health Please note that should you loose or fail the tag, you will be charged 10,00 by the Organizing Secretariat.

11 FACULTY GUIDELINES FACULTY Guidelines for Speakers and Chairs For Chairs: Locate your session Room in due time Be in the Room assigned for presentation at least 10 minutes before the beginning of the session Respect the timing allowed to the session and each presentation All presentations, discussions and questions are in English For Speakers: Follow the instructions indicated at the paragraph Audiovisual Instructions Locate your session Room in due time Be in the Room assigned for presentation at least 10 minutes before the beginning of the session to meet the Chairs Respect the timing allowed for your presentation All presentations, discussions and questions are in English AUDIOVISUAL INSTRUCTIONS A multimedial projection centre will be at the disposal of the Speakers at the ground floor of the Starhotels Rosa Grand aside the Auditorium. ONLY PC DATA PROJECTION WILL BE AVAILABLE AT THE CONFERENCE The Auditorium will be provided with the laptop. Use of one s laptop is not allowed. Should Speakers have their personal laptop, a CD Rom or a USB key, they are kindly requested to go to the multimedial projection centre to have their presentation copied. The presentation will be then forwarded through a LAN network from multimedial projection centre directly to the computer in the presentation room. We recommend to contact the multimedial projection centre the day before your presentation. At any rate, presentation material must be available: 45 minutes before for Power Point presentation on CD Rom or USB key 1 hour before for presentation on Personal Computer CERTIFICATE OF ATTENDANCE Attendance certificates will be issued on request to all regularly registered participants at the Secretariat Desk at the end of the meeting.

12 PROGRAMME June 21 st, 2018 THURSDAY WELCOME LECTURE FROM THE PRESIDENT OF IALSC Introduction: Fortunato Ciardiello (Naples, I) Immuno-oncology and precision medicine Giorgio Vittorio Scagliotti (Turin, I) FACE TO FACE I TREATMENT OF OLIGOMETASTATIC NSCLC: SURGERY VS RADIOTHERAPY AFTER SYSTEMIC TREATMENT Chair: Lucio Crinò (Meldola, I) Pro surgery Lorenzo Spaggiari (Milan, I) Pro radiotherapy Cecile Le Pechoux (Paris, F) Discussion

13 SCIENTIFIC SESSION LOCALLY ADVANCED NSCLC: FROM BENCH TO BESIDE Unrestricted grant Modera: Filippo de Marinis (Milan, I) Intervengono:. il radioterapista Umberto Ricardi (Turin, I) l oncologo Marina Chiara Garassino (Milan, I) FACE TO FACE II ANTIANGIOGENETICS IN A-NSQ NSCLC THERAPY: 1ST VS 2ND LINE USE Chair: Fortunato Ciardiello (Naples, I) Pro first-line Javier De Castro (Madrid, E) Pro second-line Maurice Perol (Lion, F) Discussion LECTURE II NEW OPTIONS IN SCLC TREATMENT Introduction: Cesare Gridelli (Avellino, I) Speaker: Naiyer Rizvi (New York, US)

14 June 22 nd, 2018 FRIDAY SCIENTIFIC SESSION SELEZIONE E SEQUENZA DI TRATTAMENTO: HOT TOPICS NEL NSCLC Unrestricted grant Modera: Filippo de Marinis (Milan, I) Intervengono. il patologo Massimo Barberis (Milan, I) l oncologo Federico Cappuzzo (Ravenna, I) SPECIAL SYMPOSIUM I THE BEST TREATMENT SEQUENCE OF NSCLC WITH ALK GENETIC ALTERATION Chair: Marina Chiara Garassino (Milan, I) Starting from Crizotinib Benjamin Besse (Paris, F) Starting from Alectinib Tony Mok (Hong Kong, HKG) New options after biological 1 st line failure Enriqueta Felip (Barcelona, E) Discussion

15 ARENA 2 ND LINE NSCLC IMMUNOTHERAPY AMONG DIFFERENT MABS Chair: Cesare Gridelli (Avellino, I) Nivolumab Suresh Ramalingam (Atlanta, US) Pembrolizumab Naiyer Rizvi (New York, US) Atezolizumab David Gandara (Sacramento, US) Interactive Discussion Lunch LECTURE III IS THE BRAIN STILL A SANCTUARY OR A NEW TARGET IN LUNG CANCER TREATMENT? Introduction: Federico Cappuzzo (Ravenna, I) Speaker: Tony Mok (Hong Kong, HKG)

16 SCIENTIFIC SESSION PROSPETTIVE FUTURE NEL NSCLC: COME CAMBIA LO SCENARIO E PERCHÈ? Urestricted grant Status quo sulle terapie di combinazione Marina Chiara Garassino (Milan, I) Quale lo scenario futuro: come cambia e perchè Filippo de Marinis (Milan, I) Discussione SCIENTIFIC SESSION LE LINEE GUIDA DEL NSCLC Unrestricted grant Introduzione: Cesare Gridelli (Avellino) NSCLC non oncogene addicted: il ruolo dell immunoterapia Filippo de Marinis (Milan, I) NSCLC oncogene addicted: il ruolo dei TKIs di seconda/terza generazione Federico Cappuzzo (Ravenna, I) Il ruolo della Patient Advocacy nella decisione terapeutica Marina Chiara Garassino (Milan, I) Linee Guida AIOT Cesare Gridelli (Avellino, I) Al termine della sessione verranno distribuite le Linee Guida AIOT aggiornate al 2018

17 June 23 rd, 2018 SATURDAY SPECIAL SYMPOSIUM III 1 ST LINE A-NSCLC IMMUNOTHERAPY: SINGLE AGENT OR COMBO Chair: Lucio Crinò (Meldola, I) Predictive biomarkers for immunotherapy Keith Kerr (Aberdeen, US) PD-1 MAbs Martin Reck (Groshansdorf, D) PD-L1 MAbs Shirish Gadgeel (Detroit, US) Discussion FACE TO FACE III THE BEST TREATMENT SEQUENCE OF NSCLC WITH EGFR MUT+ Chair: Filippo de Marinis (Milan, I) Starting with Osimertinib Suresh Ramalingam (Atlanta, US) Starting from 1st/2nd generation TKIs Luis Paz Ares (Madrid, E) Discussion

18 SPECIAL SYMPOSIUM IV NEW TARGETS: WHERE ARE WE? Chair: Nicola Normanno (Naples, I) ROS-1 Federico Cappuzzo (Ravenna, I) B-RAF David Planchard (Paris, F) c-met Christian Rolfo (Antwerp, B) Discussion CLOSING LECTURE IV NEW OPTIONS IN MPM SYSTEMIC TREATMENT Introduction Filippo de Marinis (Milan, I) Speaker: Shirish Gadgeel (Detroit, US) Closing of the conference Fortunato Ciardiello e Filippo de Marinis

19 LEVEL SPONSOR PLATINUM SPONSOR GOLD SPONSOR BRONZE SPONSOR OTHER SPONSOR

20 THIS PROGRAMME AND REGISTRATION FORM ARE AVAILABLE ON AIOT WEBSITE SCIENTIFIC SECRETARIAT AIOT - Associazione Italiana di Oncologia Toracica Via Salaria, Roma Tel. +(39) Fax (+39) oncologiatoracica@yahoo.it - ORGANIZING SECRETARIAT by SOS S.r.l. Via Salaria, Roma Tel. (+39) Fax (+39) rossella.spinetti@alice.it