CONFERENCE AND HISTOCOMPATIBILITY EUROPEAN IMMUNOGENETICS. ART AND SCIENCE: THE EVOLVING PICTURE OF IMMUNOGENETICS

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2 Committees LOCAL ORGANIZING COMMITTEE CONGRESS CHAIRMAN Valeria Miotti (IT) CONGRESS CO-CHAIRMEN Antonio Amoroso (IT) Carlo Carcassi (IT) LOCAL ORGANIZING COMMITTEE Marco Andreani (IT) Andrea Bontadini (IT) Emanuele Cozzi (IT) Maria E. Fasano (IT) Silvia Gregori (IT) Luca Mascaretti (IT) Benedetta Mazzi (IT) Lia Mele (IT) Franco Papola (IT) Antonina Piazza (IT) Francesca Quintieri (IT) Nicoletta Sacchi (IT) Manuela Testi (IT) Luca Vago (IT) ORGANIZING SECRETARIAT Planning Congressi srl Via Guelfa Bologna (Italy) Ph Ext. 130 Fax m.mura@planning.it EFI EXECUTIVE COMMITTEE Elissaveta Naumova (BG), President Joannis Mytilineos (DE) President Elect Mats Bengtsson (SE), Secretary Dave Roelen (NL), Deputy Secretary Gwendaline Guidicelli (FR), Treasurer Katia Gagne (FR), Deputy Treasurer EFI COUNCILLORS Pierre-Antoine Gourraud (FR) Teresa Kauke (DE) Neema Mayor (UK) Valeria Miotti (IT) Fatma Oguz (TR) Jean Villard (CH) SCIENTIFIC COMMITTEE AND REVIEWERS CHAIR Katharina Fleischhauer (DE) MEMBERS Rainer Blasczyk (DE) Silvia Gregori (IT) Sebastiaan Heidt (NL) James Robinson (UK) Ludvig Sollid (NO) James Traherne (UK) John Trowsdale (UK) Luca Vago (IT) Lotte Wieten (NL)

WELCOME ADDRESSES Dear Colleagues and Friends, The 32 nd European Immunogenetics and Histocompatibility Conference, joint with the 25 th AIBT( Italian Society Biology) annual meeting, will be held in

3 WELCOME ADDRESSES Dear Colleagues and Friends, The 32 nd European Immunogenetics and Histocompatibility Conference, joint with the 25 th AIBT( Italian Society Biology) annual meeting, will be held in Venice, Italy from 9 th to 12 th of May, Art and Science: the evolving picture of Immunogenetics is the motto of EFI2018 that reflects the dynamism of the Immunogenetics World and its ability to get involved in new addictive biomedical fields, like Leonardo s masterpiece. I am confident that the meeting will be interesting and exciting, enriching you with the most recent updates in Tissue Typing, Immunogenetics immunology. The conference will take place in the historical buildings of Palazzo del Cinema and Palazzo del Casinò, located in Venice Lido, the quiet, peaceful and green narrow island that stretches between the open sea and the lagoon, just 15 minutes far from St. Mark s Square. Marvellous Venice, where, everybody knows, there is no traffic jam and you can wander around the labyrinth of narrow cobbled streets and over the countless bridges that criss-cross the canals. You shall not rush and you might lose track of time. Every corner is unique and worth a look for its artistic value or romantic atmosphere. You can get about Venice by water buses, water-taxis or Gondolas, which allows you to visit canals and the lagoon. Don t miss the chance to see Ponte dei Sospiri (Bridge of Sighs) where the convicts saw the lagoon before their imprisonment, sighing at their final view of beautiful Venice through the window before being taken down to their cells; Canal Grande (Grand Canal); Rialto Bridge, Churches, Art-galleries, Murano (famous for its glass works) and Burano (famous for the lace shops). It is a great honour and pleasure to invite you to such a unique, romantic, slow, fascinating place named Venice. Looking forward to seeing you all Valeria Miotti On behalf of AIBT and Conference Co-Chairs Carlo Carcassi and Antonio Amoroso

4 ASSOCIATED MEETINGS Tuesday 8 May :30-17:30 ESHI diploma examination BUY ROOM - PALAZZO CASINÒ (2 nd FLOOR) Wednesday 9 May 2018 MARTINELLI ROOM - PALAZZO CASINÒ (2 nd FLOOR) 9:00-16:30 Accreditation Commissioners Meeting 8:30-9:30 EBTI Assembly meeting 11:30-18:30 IBMDR Meeting 9:30-17:00 Accreditation Inspectors Workshop Wednesday 9 May :30-16:00 External Proficiency Testing Committee 13:30-17:00 Education Committee 8:30-16:30 Executive Committee Meeting CASINÒ ROOM - PALAZZO CASINÒ (1 st FLOOR) PALAZZO CINEMA FOYER AMICI ROOM - PALAZZO CASINÒ (2 nd FLOOR) BUY ROOM - PALAZZO CASINÒ (2 nd FLOOR) MANGANO ROOM - PALAZZO CASINÒ (2 nd FLOOR) 8:30-16:00 Standards Committee Meeting ROSSI DRAGO ROOM - PALAZZO CASINÒ (2 nd FLOOR) CASINÒ ROOM - PALAZZO CASINÒ (1 st FLOOR) 14:00-15:00 Population Genetics Working Group (close meeting) Katharina Fleischhauer 15:00-16:30 Open Meeting of the Population Genetics Working Group Alicia Sanchez-Mazas Thursday 10 May :00-12:00 Scientific Committee Meeting BUY ROOM - PALAZZO CASINÒ (2 nd FLOOR) MARTINELLI ROOM - PALAZZO CASINÒ (2 nd FLOOR) 12:15-14:30 Executive Committee and Co-ordinators meeting

5 AIBT ANNUAL MEETING Accreditato ECM Wednesday 9 May 2018 PERLA ROOM - PALAZZO CASINÒ (1 st FLOOR) Wednesday 9 May 2018 PERLA ROOM - PALAZZO CASINÒ (1 st FLOOR) 9:00 Apertura lavori 1 SESSIONE Moderatori: Valeria Miotti, Manuela Testi 9:30 Il donatore non familiare, adulto e cord: quali prospettive nell era del trapianto aploidentico Nicoletta Sacchi 10:00 Anticorpi DSA nel Trapianto di CSE, gestione e desensibilizzazione Andrea Bontadini 10:30 Metodologia di studio del chimerismo in relazione alle diverse tipologie di trapianto di CSE: ricaduta clinica Marco Andreani 11:00 Nuovi targets della risposta immune umorale nel trapianto d organo Emanuele Cozzi 2 SESSIONE Moderatori: Lia Mele, Antonina Piazza 11:45 Epigenetica e nuove tecnologie: cosa cambia nell associazione HLA e malattie immunomediate Carlo Carcassi 12:15 Il Controllo di qualità Esterno Francesca Quintieri 13:30 Lunch 14:45 AIBT nella storia V. Misefari 15:15 Conclusione lavori 15:15-16:30 Assemblea dei Soci 11:30 Coffee break

6 PROGRAMME Wednesday 9 May 2018 Opening Ceremony 17:30-18:00 Welcome Addresses Valeria Miotti, Carlo Carcassi, Antonio Amoroso, Elissaveta Naumova, Alessandro Nanni Costa 18:00-18:30 In memory of Jon van Rood Frans Claas 18:30-18:55 Julia Bodmer Award Katharina Fleischhauer 18:55-19:00 HLA Award Steven Marsh 19:00-19:30 Ceppellini Lecture Lorenzo Moretta Chairperson: Elissaveta Naumova 19:30-20:00 Sounds from Italy - Classic and cinema 20:00-21:30 Welcome Reception Thursday 10 May 2018 PLENARY SESSION 1 Governance of immune-modulation in transplantation Chairpersons: Frans Claas, Silvia Gregori 8:30-9:00 Mesenchimal stem cells in transplantation Katarina Le Blanc 9:00-9:30 Exosome Adrian E. Morelli 9:30-10:00 Innate lymphoid cells Hergen Spits 10:00-10:20 Coffee break & Poster viewing 10:20-11:50 Meet the Expert 1 - ESHI Diploma Marco Andreani, David Turner 12:00-13:00 Luncheon Session - CareDx 13:30-14:30 Luncheon Session - Immucor CASINÒ ROOM - PALAZZO CASINÒ (1 st FLOOR) 14:40-16:10 Meet the Expert 2 - EPT External proficiency testing Falko Markus Heinemann Topics Extending the Spectrum of EPT in H&I EPT in H&I: From History to New Developments Organization of EPT: Schemes, Workshops and Inter-Laboratory Exchanges Specialist EPT Schemes: HNA, HPA, mhag and KIR The Impact of New Technology on EPT: Next Generation Sequencing and Single Antigen Bead tests - Result based or method based assessment?

7 Thursday 10 May 2018 MOSAICI 1 ROOM - PALAZZO CASINÒ (3 rd FLOOR) 10:20-11:50 Oral Session 1: MHC Evolution - Anthropology - Population Genetics Chairpersons: Pierre-Antonie Gourraud, Alicia Sanchez-Mazas 14:40-16:10 Oral Session 3: Immunotherapy - Gene Therapy - Cellular Therapy Chairpersons: Rainer Blasczyk, Mats Bengtsson 10:20-11:50 Oral Session 2: New Technologies and Bioinformatics Chairpersons: Emanuele Cozzi, Eric Spierings 12:00-13:00 Luncheon Session - GenDx MOSAICI 2 ROOM - PALAZZO CASINÒ (3 rd FLOOR) 13:30-14:30 Luncheon Session - Omixon 14:40-16:10 Oral Session 4: Haematopoietic Stem Cell Transplantation Chairpersons: Manuela Testi, Jean Villard Thursday 10 May 2018 PERLA ROOM - PALAZZO CASINÒ (1 st FLOOR) 10:20-11:50 Teaching Session 1 How NGS technology is changing the way of HLA typing Joannis Mytilineos, Sarah Peacock 12:00-13:00 Luncheon Session - One Lambda 14:40-16:10 Teaching Session 2 14:40-15:05 The clinical relevance of de novo HLA antibodies in renal transplantation Antonina Piazza 15:05-15:30 The clinical relevance of de novo HLA antibodies in heart transplantation Jennifer McCaughan 15:30-15:55 The clinical relevance of de novo HLA antibodies in pancreas and islet transplantation David Turner 15:55-16:10 Q&A 16:10-16:30 Coffee break & Poster viewing

8 Thursday 10 May 2018 PLENARY SESSION 2 Solid Organ Transplantation Chairpersons: Antonio Amoroso, Joannis Mytilineos 16:30-17:00 T regulatory cell based therapy in promoting tolerance solid organ transplantation Giovanna Lombardi 17:00-17:30 Desensitization in SOT Christophe Legendre 17:30-18:00 Novel Biomarkers for allograft rejection in SOT Minnie M. Sarwal Friday 11 May 2018 PLENARY SESSION 3 HSCT Current clinical perspectives Chairpersons: Luca Vago, Lotte Wieten 8:30-9:00 Haplo settings or Impact of non shared haplotype on haplotransplant Leo Luznik 9:00-9:30 Adoptive Immunotherapies in HSCT Chiara Bonini 9:30-10:00 Tregs in HSCT Maria Grazia Roncarolo 18:00-19:30 Poster Session (Wine&Cheese) PALAZZO DEL CASINÒ (3 rd FLOOR) MOSAICI 1 ROOM - PALAZZO CASINÒ (3 rd FLOOR) 10:20-11:50 Oral Session 5: Solid Organ Transplantation Chairpersons: Franco Papola, Dave Roelen 12:00-13:00 Luncheon Session - Bag Healthcare 14:40-16:10 Oral Session 7: Reproduction, Autoimmunity, Infection & Cancer Chairpersons: Andrea Bontadini, Antonio Martinho

9 Friday 11 May :20-11:50 Oral Session 6: NK and Miscellaneous Chairpersons: Benedetta Mazzi, Caner Susal 13:30-14:30 Luncheon Session - Histogenetics MOSAICI 2 ROOM - PALAZZO CASINÒ (3 rd FLOOR) PERLA ROOM - PALAZZO CASINÒ (1 st FLOOR) 10:20-11:50 Teaching Session 3 Tools for a successful HSCT: evaluation of HLA allele frequencies, anti-hla antibodies, structural and expression models for permissive mismatches Marcelo A. Fernández-Viña, Katharina Fleischhauer Allele and haplotype frequencies: How variation affects donor searches Anti-HLA antibodies: Role of DSA in HLA mismatched transplantation Coding and non-coding HLA variation: Relationship between T-cell epitopes and HLA expression levels for permissive mismatches in HSCT 12:00-13:00 Luncheon Session - One Lambda PERLA ROOM - PALAZZO CASINÒ (1 st FLOOR) 14:40-16:10 Teaching Session 4 How to prepare for an inspection: demonstrating how quality standards are Met Andrea Harmer, Luca Mascaretti Friday 11 May 2018 SPECIAL JOINT SESSION WMDA and EFI Chairpersons: Lydia Foeken, Elissaveta Naumova, Nicoletta Sacchi 14:40-15:10 Past, Present and future of unrelated Donor registries Lidia Foeken 15:10-15:40 Pharma-economics of CB banking in the haplo era Sergio Querol-Giner 15:40-16:10 How to choose the best unrelated HSC donor? Carolyn Katovich Hurley 16:10-16:30 Coffee break & Poster viewing PLENARY SESSION 4 Immunogenetics beyond HLA Chairpersons: Marcel Tilanus, John Trowsdale 16:30-17:00 Immunogenetics in Autoimmunity Francesco Cucca 17:00-17:30 Epigenetic reprogramming in HSCT Angelo Lombardo 17:30-18:00 GWAS in Multiple Sclerosis Stephen Sawcer 18:00-19:30 EFI General Assembly PERLA ROOM - PALAZZO CASINÒ (1 st FLOOR)

10 Saturday 12 May :30-10:00 Best Abstract Session Chairpersons: Katharina Fleishhauer, Luca Mascaretti 10:00-10:30 17 IHW report The 17 th International HLA & Immunogenetics Workshop Marcelo A. Fernández-Viña The 18 th International HLA & Immunogenetics Workshop 2021 Eric Spierings 10:30-10:50 Coffee break PLENARY SESSION 5 New Frontiers in Immunogenetics Chairpersons: Elissaveta Naumova, David Turner 10:50-11:20 Single Cell Technologies Ido Amit 11:20-11:50 Immunopeptidome Markus Loeffler 11:50-12:20 Neoantigens in Cancer Immunotherapy Catherine J. Wu Saturday 12 May 2018 Closing Ceremony Chairpersons: Valeria Miotti, Elissaveta Naumova 12:20-12:50 Closing Lecture Chairpersons: Carlo Carcassi, Valeria Miotti Leonardo da Vinci: the prototype of Art & Science man Pietro Cesare Marani Jon van Rood Award and Best Abstract Awards Committee Chair: Frans Claas Best Poster Awards Committee: Marco Andreani, Carlo Carcassi, Luca Mascaretti, Sandra Tafulo, Hien Tran EFI 2019, Lisbon Antonio Martinho Closing Remarks

11 SPEAKERS - CHAIRS

12 Speakers - Chairs Amit Ido, Rehovot - Israel Amoroso Antonio, Torino - Italy Andreani Marco, Roma - Italy Bengtsson Mats, Uppsala - Sweden Blasczyk Rainer, Hannover - Germany Bonini Chiara, Milano - Italy Bontadini Andrea, Bologna - Italy Carcassi Carlo, Cagliari - Italy Claas Frans, Leiden - The Netherlands Cozzi Emanuele, Padova - Italy Cucca Francesco, Sassari - Italy Fernandez-Vina Marcelo A., Stanford - USA Fleischhauer Katharina, Essen - Germany Foeken Lydia, Leiden - The Netherlands Gourraud Pierre-Antoine, Nantes - France Gregori Silvia, MIlano - Italy Harmer Andrea, Sheffield - United Kingdom Heinemann Falko Markus, Essen - Germany Hurley Carolyn Katovich, Washington D.C - USA Le Blanc Katarina, Stockholm - Sweden Legendre Christophe, Paris - France Loeffler Markus, Tübingen - Germany Lombardi Giovanna, London - United Kingdom Lombardo Angelo, Milano - Italy Luznik Leo, Baltimore - USA Marani Pietro Cesare, Milano - Italy Marsh Steven, London - United Kingdom Martinho Antonio, Coimba - Portugal Mascaretti Luca, Trieste - Italy Mazzi Benedetta, Milano - Italy Miotti Valeria, Udine - Italy Morelli Adrian E., Pittsburgh - USA Mytilineos Joannis, Ulm - Germany Nanni Costa Alessandro, Roma - Italy Naumova Elissaveta, Sofia - Bulgaria Papola Franco, L Aquilla - Italy Peacock Sarah, Cambridge - United Kingdom Piazza Antonina, Roma - Italy Querol-Giner Sergio, Barcelona - Spain Roelen Dave, Leiden - The Netherlands Roncarolo Maria Grazia, Stanford - USA Sacchi Nicoletta, Genoa - Italy Sanchez-Mazas Alicia, Genève - Switzerland Sarwal Minnie M., San Francisco - USA Sawcer Stephen, Cambridge - United Kingdom Spierings Eric, Utrecht - The Netherlands Spits Hergen, Amsterdam - The Netherlands Susal Caner, Heidelberg - Germany Testi Manuela, Roma - Italy Tilanus Marcel, Maastricht - The Netherlands Trowsdale John, Cambridge - United Kingdom Turner David, Edinburgh - United Kingdom Vago Luca, Milano - Italy Villard Jean, Geneva - Switzerland Wieten Lotte, Maastricht - The Netherlands Wu Catherine J., Boston - USA

CONFERENCE AND HISTOCOMPATIBILITY EUROPEAN IMMUNOGENETICS. ART AND SCIENCE: THE EVOLVING PICTURE OF IMMUNOGENETICS

CONFERENCE AND HISTOCOMPATIBILITY EUROPEAN IMMUNOGENETICS. ART AND SCIENCE: THE EVOLVING PICTURE OF IMMUNOGENETICS JOINT EFI-AIBT www.efi2018.org JOINT EFI-AIBT Committees LOCAL ORGANIZING COMMITTEE CONGRESS CHAIRMAN Valeria Miotti (IT) CONGRESS CO-CHAIRMEN Antonio Amoroso (IT) Carlo Carcassi (IT) LOCAL ORGANIZING