CONFERENCE AND HISTOCOMPATIBILITY EUROPEAN IMMUNOGENETICS. ART AND SCIENCE: THE EVOLVING PICTURE OF IMMUNOGENETICS

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1 ART AND SCIENCE: THE EVOLVING PICTURE JOINT EFI-AIBT VENICE LIDO, MAY 9-2, 208

2 ART AND SCIENCE: THE EVOLVING PICTURE VENICE LIDO, MAY 9-2, 208

3 JOINT EFI-AIBT TABLE OF CONTENTS Committees... 4 Welcome Addresses... 7 General Information... 8 Associated Meetings... 4 AIBT Annual Meeting... 6 Programme... 8 Wednesday... 8 Thursday... 9 Friday... 3 Saturday Poster Presentations Speakers - Chairs Authors Index Exhibition Plan and Listing Floor Plan

4 ART AND SCIENCE: THE EVOLVING PICTURE VENICE LIDO, MAY 9-2, 208 Committees LOCAL ORGANIZING COMMITTEE CONGRESS CHAIRMAN Valeria Miotti (IT) CONGRESS CO-CHAIRMEN Antonio Amoroso (IT) Carlo Carcassi (IT) LOCAL ORGANIZING COMMITTEE Marco Andreani (IT) Andrea Bontadini (IT) Emanuele Cozzi (IT) Maria E. Fasano (IT) Silvia Gregori (IT) Luca Mascaretti (IT) Benedetta Mazzi (IT) Lia Mele (IT) Franco Papola (IT) Antonina Piazza (IT) Francesca Quintieri (IT) Nicoletta Sacchi (IT) Manuela Testi (IT) Luca Vago (IT) ORGANIZING SECRETARIAT Planning Congressi srl Via Guelfa Bologna (Italy) Ph Ext. 30 Fax m.mura@planning.it 4

5 JOINT EFI-AIBT EFI EXECUTIVE COMMITTEE Elissaveta Naumova (BG), President Joannis Mytilineos (DE) President Elect Mats Bengtsson (SE), Secretary Dave L. Roelen (NL), Deputy Secretary Gwendaline Guidicelli (FR), Treasurer Katia Gagne (FR), Deputy Treasurer EFI COUNCILLORS Pierre-Antoine Gourraud (FR) Teresa Kauke (DE) Neema Mayor (UK) Valeria Miotti (IT) Fatma Oguz (TR) Jean Villard (CH) SCIENTIFIC COMMITTEE AND REVIEWERS CHAIR Katharina Fleischhauer (DE) MEMBERS Rainer Blasczyk (DE) Silvia Gregori (IT) Sebastiaan Heidt (NL) James Robinson (UK) Ludvig Sollid (NO) James Traherne (UK) John Trowsdale (UK) Luca Vago (IT) Lotte Wieten (NL) 5

6 ART AND SCIENCE: THE EVOLVING PICTURE VENICE LIDO, MAY 9-2, 208

7 JOINT EFI-AIBT WELCOME ADDRESSES Dear Colleagues and Friends, The 32 nd European Immunogenetics and Histocompatibility Conference, joint with the 25 th AIBT( Italian Society Biology) annual meeting, will be held in Venice, Italy from 9 th to 2 th of May, 208. Art and Science: the evolving picture of Immunogenetics is the motto of EFI208 that reflects the dynamism of the Immunogenetics World and its ability to get involved in new addictive biomedical fields, like Leonardo s masterpiece. I am confident that the meeting will be interesting and exciting, enriching you with the most recent updates in Tissue Typing, Immunogenetics immunology. The conference will take place in the historical buildings of Palazzo del Cinema and Palazzo del Casinò, located in Venice Lido, the quiet, peaceful and green narrow island that stretches between the open sea and the lagoon, just 5 minutes far from St. Mark s Square. Marvellous Venice, where, everybody knows, there is no traffic jam and you can wander around the labyrinth of narrow cobbled streets and over the countless bridges that criss-cross the canals. You shall not rush and you might lose track of time. Every corner is unique and worth a look for its artistic value or romantic atmosphere. You can get about Venice by water buses, water-taxis or Gondolas, which allows you to visit canals and the lagoon. Don t miss the chance to see Ponte dei Sospiri (Bridge of Sighs) where the convicts saw the lagoon before their imprisonment, sighing at their final view of beautiful Venice through the window before being taken down to their cells; Canal Grande (Grand Canal); Rialto Bridge, Churches, Art-galleries, Murano (famous for its glass works) and Burano (famous for the lace shops). It is a great honour and pleasure to invite you to such a unique, romantic, slow, fascinating place named Venice. Looking forward to seeing you all Valeria Miotti On behalf of AIBT and Conference Co-Chairs Carlo Carcassi and Antonio Amoroso 7

8 ART AND SCIENCE: THE EVOLVING PICTURE VENICE LIDO, MAY 9-2, 208 GENERAL INFORMATION VENUE The Conference will take place in Venice Lido, at Palazzo del Cinema and Palazzo del Casinò. Lungomare Guglielmo Marconi, Lido di Venezia The Palazzo del Cinema is the main facility and screening theatre of the Venice Film Festival. It was built according to the modernist PALAZZO CINEMA trends of the 930s, and inaugurated on 0 th August 937 on the occasion of the fifth edition of the festival. The Palazzo del Casinò was designed by the Chief Engineer of the City of Venice Eugenio Miozzi in the Rationalist style, influenced by the Fascist architecture of the 930s and built in the record time of 8 months in 938. PALAZZO CASINÒ 8

9 JOINT EFI-AIBT REGISTRATION AND INFORMATION DESKS The registration desks are located on Level. OPENING HOURS Wednesday 9 May :30-20:00 Thursday 0 May :00-9:00 Friday May :00-9:00 Saturday 2 May :00-4:00 ON SITE REGISTRATION FEES Member 560 Euro Non Member 620 Euro Student 395 Euro Technician 395 Euro Accompanying Person 0 Euro Gala Dinner 70 Euro REGISTRATION INCLUDES: VAT Access to the conference sessions (not included for Accompanying Persons) Opening Ceremony and Welcome Reception Coffee Breaks Lunches VENEZIA UNICA City Card COFFEE BREAKS Coffee and refreshments will be served to delegates at several points at the exhibition area. LUNCH BOX Tickets are required for the lunch box and are provided with the registration package. Additional tickets for guests can be purchased through the Registration desk. 9

10 ART AND SCIENCE: THE EVOLVING PICTURE VENICE LIDO, MAY 9-2, 208 GENERAL INFORMATION PUBLIC TRANSPORTATION Venice s official City Pass VENEZIA UNICA is a card that offers three days of public transportation use with the ACTV Company in the city area (the card will be activated for the whole days of May 0, and 2). Warning: The fare includes the transport of only one piece of luggage and its three dimensions must not exceed 50 cm. The card will be delivered at the Congress Registration Desk. This card allows you to catch all vaporetto and buses in the City of Venice and buses in Mestre. The Tronchetto parking area in Venice is not reachable by bus, but only by the people mover. PLEASE NOTE THAT PEOPLE MOVER FARE IS NOT INCLUDED IN THE VENEZIA UNICA CARD. The card also includes the free use of the speedboat from Punta Sabbioni to Venice Lido, but it does NOT include bus transportation in Punta Sabbioni (one way fare,50 ). The public transportation from/to Marco Polo Airport is provided by another company, named Alilaguna, and is not included in Venezia Unica card. APP Full program and more information regarding the Conference are available at the 32 nd EFI conference application for ios and Android. WI-FI Free Wi-Fi is provided for all delegates and Exhibitors attending the conference. EFI BOOTH The EFI Booth is situated in the Exhibition Hall on level 3. Membership secretary is available: Thursday 0 May :30-7:00 Friday May :30-7:00 0

11 JOINT EFI-AIBT SPEAKER READY ROOM The Speaker Ready room is located on level. All speakers should deliver their presentations at least 2 hours prior to their speech. OPENING HOURS Wednesday 9 May 208 5:00-8:30 Thursday 0 May :00-9:00 Friday May :00-8:30 Saturday 2 May :00-3:00 POSTERS The Poster Area is located on level 3. The poster panels will be numbered. Please refer to the final poster number of your submission which has been communicated to you earlier. Posters can be mounted on Thursday May 0 th (from 8:00-0:30) and should be removed on Saturday, May 2 th by 0:00. Any posters remaining on poster boards after this time will be disposed of by the organizers. Posters should be attached to poster boards using double sided tape - supply of the tape will be available at the poster area for all poster presenters. Posters will be presented during the Poster Session in the late afternoon of Thursday, May 0 th. The presenting author should be available beside his/her poster in order to discuss the data with the attendants. AIBT ANNUAL MEETING Please note that the official language of the AIBT Meeting will be Italian. No simultaneous translation will be provided. AIBT MEETING - CONTINUING MEDICAL EDUCATION (CME) Planning Congressi S.r.l. is a CME Provider - identification code no and has assigned to the event no. 3,5 credits for Biologists, Physicians and Technicians, Chemists. Please be aware that for the acquisition of credits it is mandatory to have attended the 00% of the whole duration of the congress and selected at least the 75% of correct answers of the CME questionnaire.

12 ART AND SCIENCE: THE EVOLVING PICTURE VENICE LIDO, MAY 9-2, 208 GENERAL INFORMATION EFI CONGRESS - ASHI AND CPE CREDITS The Scientific Committee has applied for ASHI and CPE credits EXHIBITION The Exhibition will be held on level and 3. OPENING HOURS Wednesday 9 May :00-9:00 Thursday 0 May :00-9:30 Friday May :00-9:00 SOCIAL PROGRAM EFI Inspectors Dinner (by invitation only) Tuesday 8 May, 20:30 - La Favorita Restaurant Welcome Reception Wednesday 9 May, 9:30 - Palazzo Cinema Foyer Tulip Run (Sponsored by GENDX) Thursday 0 May, 07:00-08:00 Wine and Cheese at Poster Session Area Thursday 0 May, 8:00-9:30 Palazzo del Casinò (3 rd floor) Ceppellini Dinner (by invitation only) Thursday 0 May, 20:30 Da Celeste Restaurant - Pellestrina Island Speakers Dinner (by invitation only) Thursday 0 May, 20:30 Relais Alberti, Venice Lido Conference Gala Dinner (additional fee) Friday May, 20:45 Grand Hotel Excelsior, Venice Lido 2

13 JOINT EFI-AIBT ASSOCIATED MEETINGS AIBT ANNUAL MEETING PROGRAMME

14 ART AND SCIENCE: THE EVOLVING PICTURE VENICE LIDO, MAY 9-2, 208 ASSOCIATED MEETINGS Tuesday 8 May 208 8:30-7:30 ESHI diploma examination Chairperson: David Turner BUY ROOM - PALAZZO CASINÒ (2 nd FLOOR) 8:30-9:30 EBTI Assembly meeting Chairperson: Joannis Mytilineos :30-8:30 IBMDR Meeting Chairperson: Nicoletta Sacchi CASINÒ ROOM - PALAZZO CASINÒ ( st FLOOR) 9:30-7:00 Accreditation Inspectors Workshop Chairperson: Andrea Harmer FOYER - PALAZZO CINEMA Wednesday 9 May 208 8:30-6:00 External Proficiency Testing Committee Chairperson: Falko Markus Heinemann AMICI ROOM - PALAZZO CASINÒ (2 nd FLOOR) 3:30-7:00 Education Committee Chairperson: David Turner BUY ROOM - PALAZZO CASINÒ (2 nd FLOOR) 8:30-6:30 Executive Committee Meeting Chairperson: Elissaveta Naumova MANGANO ROOM - PALAZZO CASINÒ (2 nd FLOOR) 4

15 JOINT EFI-AIBT Wednesday 9 May 208 MARTINELLI ROOM - PALAZZO CASINÒ (2 nd FLOOR) 9:00-6:30 Accreditation Commissioners Meeting Chairperson: Andrea Harmer 8:30-6:00 Standards Committee Meeting Chairperson: Juha Peräsaari ROSSI DRAGO ROOM - PALAZZO CASINÒ (2 nd FLOOR) CASINÒ ROOM - PALAZZO CASINÒ ( st FLOOR) 4:00-5:00 Population Genetics Working Group (close meeting) Chairperson: Katharina Fleischhauer 5:00-6:30 Open Meeting of the Population Genetics Working Group Chairperson: Alicia Sanchez-Mazas Thursday 0 May 208 0:00-2:00 Scientific Committee Meeting Chairperson: Katharina Fleischhauer BUY ROOM - PALAZZO CASINÒ (2 nd FLOOR) MARTINELLI ROOM - PALAZZO CASINÒ (2 nd FLOOR) 2:5-4:30 Executive Committee and Co-ordinators meeting Chairperson: Elissaveta Naumova 5

16 ART AND SCIENCE: THE EVOLVING PICTURE VENICE LIDO, MAY 9-2, 208 AIBT ANNUAL MEETING Accreditato ECM Wednesday 9 May 208 PERLA ROOM - PALAZZO CASINÒ ( st FLOOR) 9:00 Apertura lavori WEDNESDAY SESSIONE Moderatori: Valeria Miotti, Manuela Testi 9:30 Il donatore non familiare, adulto e cord: quali prospettive nell era del trapianto aploidentico Nicoletta Sacchi 0:00 Anticorpi DSA nel Trapianto di CSE, gestione e desensibilizzazione Andrea Bontadini 0:30 Metodologia di studio del chimerismo in relazione alle diverse tipologie di trapianto di CSE: ricaduta clinica Marco Andreani :00 Nuovi targets della risposta immune umorale nel trapianto d organo Emanuele Cozzi :30 Coffee break 6

17 JOINT EFI-AIBT Wednesday 9 May 208 PERLA ROOM - PALAZZO CASINÒ ( st FLOOR) 2 SESSIONE Moderatori: Lia Mele, Antonina Piazza :45 Epigenetica e nuove tecnologie: cosa cambia nell associazione HLA e malattie immunomediate Carlo Carcassi 2:5 Il Controllo di qualità Esterno Francesca Quintieri WEDNESDAY 3:30 Lunch 4:45 AIBT nella storia V. Misefari 5:5 Conclusione lavori 5:5-6:30 Assemblea dei Soci 7

18 ART AND SCIENCE: THE EVOLVING PICTURE VENICE LIDO, MAY 9-2, 208 PROGRAMME Wednesday 9 May 208 OPENING CEREMONY 7:30-8:00 Welcome Addresses Valeria Miotti, Carlo Carcassi, Antonio Amoroso, Elissaveta Naumova, Alessandro Nanni Costa AUDITORIUM - PALAZZO CINEMA WEDNESDAY 8:00-8:30 In memory of Jon van Rood Frans H.J. Claas 8:30-8:55 Julia Bodmer Award Katharina Fleischhauer 8:55-9:00 HLA Award Steven G.E. Marsh 9:00-9:30 Ceppellini Lecture Lorenzo Moretta Chairperson: Elissaveta Naumova 9:30-20:00 Sounds from Italy - Classic and cinema 20:00-2:30 Welcome Reception 8

19 JOINT EFI-AIBT Thursday 0 May 208 PLENARY SESSION Governance of immune-modulation in transplantation Chairpersons: Frans H.J. Claas, Silvia Gregori 8:30-9:00 Mesenchimal stem cells in transplantation Katarina K. Le Blanc 9:00-9:30 Exosome Adrian E. Morelli 9:30-0:00 Innate lymphoid cells Hergen Spits AUDITORIUM - PALAZZO CINEMA 0:00-0:20 Coffee break & Poster viewing PALAZZO CASINÒ THURSDAY 9

20 ART AND SCIENCE: THE EVOLVING PICTURE VENICE LIDO, MAY 9-2, 208 Thursday 0 May 208 PARALLEL SESSIONS CASINÒ ROOM - PALAZZO CASINÒ ( st FLOOR) THURSDAY 0:20-:50 Meet the Expert - ESHI Diploma Marco Andreani, David Turner Overview of the ESHI Diploma David Turner Preparation for the Application and Examination Marco Andreani New EFI CME/CPD scheme David Turner Q&A 2:00-3:00 Luncheon Session - CareDx 3:00-3:30 Lunch 3:30-4:30 Luncheon Session - Immucor 4:40-6:0 Meet the Expert 2 - EPT External proficiency testing Falko Markus Heinemann Extending the Spectrum of EPT in H&I EPT in H&I: From History to New Developments Organization of EPT: Schemes, Workshops and Inter-Laboratory Exchanges Specialist EPT Schemes: HNA, HPA, mhag and KIR The Impact of New Technology on EPT: Next Generation Sequencing and Single Antigen Bead tests - Result based or method based assessment? 20

21 JOINT EFI-AIBT Thursday 0 May 208 PARALLEL SESSIONS MOSAICI ROOM - PALAZZO CASINÒ (3 rd FLOOR) 0:20-:50 Oral Session : MHC Evolution - Anthropology - Population Genetics Chairpersons: Pierre-Antoine Gourraud, Alicia Sanchez-Mazas O9 O0 O O2 O3 O4 AGE-DEPENDENT CHANGES IN REGULATION OF HLA-DQ GENE EXPRESSION Marie Cerna, Martin Chmel, Michael Hudec, Adela Rihova, Elena Silhova 2 Charles University, Third Faculty of Medicine, Prague, Czech Republic - 2 University Hospital Kralovske Vinohrady, Prague, Czech Republic THE DISTRIBUTION OF HUMAN LEUKOCYTE ANTIGEN A AND B GENES IN POPULATIONS IS STRONGLY SHAPED BY THEIR FUNCTIONAL RELATIONSHIP Da Di, Jose M. Nunes, Alicia Sanchez-Mazas University of Geneva, Geneva, Switzerland HLA ALLELE AND HAPLOTYPE FREQUENCIES CHARACTERIZED USING NEXT-GENERATION SEQUENCING METHODS IN UNRELATED WORLD-WIDE POPULATIONS: SUMMARY FROM THE 7TH INTERNATIONAL HLA AND IMMUNOGENETICS WORKSHOP Lisa E. Creary, Chia-Jung Chang 2, Gonzalo Montero-Martin, Kalyan C. Mallempati 3, Sridevi Gangavarapu 3, Kazutoyo Osoegawa 3, Tamara Vayntrub 3, Marcelo A. Fernández-Viña Stanford University School of Medicine, Palo Alto, United States of America - 2 Stanford Genome Technology Center, Palo Alto, United States of America - 3 Stanford Blood Center, Palo Alto, United States of America THE MICRORNA BINDING-SITE REGION OF MHC GENES PLACED IN AN EVOLUTIONARY CONTEXT Corrine M.C. Heijmans, Cristy Verzijl, Hans J.H.A. Rijnaard, Jeffrey Oliveira, Kaat Tielens, Natasja G. de Groot, Ronald E. Bontrop Biomedical Primate Research Centre, Rijswijk, Netherlands HLA CLASS I HAPLOTYPE DIVERSITY IS CONSISTENT WITH SELECTION FOR FREQUENT EXISTING HAPLOTYPES Voram Louzoun, Loren Gragert 2, Martin Maiers 3, Idan Alter, Stephanie Fingerson 3 Bar Ilan University, Ramat Gan, Israel - 2 Tulane University, New Orleans, United States of America - 3 National Marrow Donor Program, Minneapolis, MN, United States of America MANY MHC-B ALLELES OF THE BONOBO SHARE SIMILAR FEATURES WITH HLA ALLELES THAT ARE ASSOCIATED WITH PROTECTION FROM MALARIA Natasja G. de Groot, Corrine M.C. Heijmans, Philippe Helsen 2, Jeroen M.G. Stevens 2, Ronald E. Bontrop Biomedical Primate Research Centre, Rijswijk, Netherlands - 2 Royal Zoological Society of Antwerp, Antwerp, Belgium THURSDAY 2

22 ART AND SCIENCE: THE EVOLVING PICTURE VENICE LIDO, MAY 9-2, 208 Thursday 0 May 208 PARALLEL SESSIONS O5 O6 EVOLUTIONARY FATE OF NEW ALLELES Pedro Cano Moffitt Cancer Center, Tampa, United States of America MOSAICI ROOM - PALAZZO CASINÒ (3 rd FLOOR) ANCIENT ORIGIN OF TWO CLADES OF DPB ALLELES Gerhard Schöfl, Steffen Klasberg, Kathrin Lang, Alexander H. Schmidt 2, Vinzenz Lange DKMS Life Science Lab, Dresden, Germany - 2 DKMS, Tübingen, Germany 3:00-3:30 Lunch THURSDAY 4:40-6:0 Oral Session 3: Immunotherapy - Gene Therapy - Cellular Therapy Chairpersons: Rainer Blasczyk, Mats Bengtsson O25 O26 O27 O28 NKG2A EXPRESSION IS NOT PER SE DETRIMENTAL FOR THE ANTI-MULTIPLE MYELOMA ACTIVITY OF HIGH DOSE IL-2 ACTIVATED NATURAL KILLER CELLS IN AN IN VITRO SYSTEM MIMICKING THE TUMOR MICROENVIRONMENT Niken M. Mahaweni, Femke Ehlers, Subhashis Sarkar, Johanna W. H. Janssen, Marcel G. Tilanus, Gerard M. J. Bos, Lotte Wieten Maastricht University Medical Center, Maastricht, Netherlands ALLOREACTIVE NATURAL KILLER CELL THERAPY AS NOVEL APPROACH FOR BREAST CANCER Femke Ehlers, Michel van Gelder, Nicky Beelen, Marcel Tilanus, Marjolein Smits, Loes Kooreman, Gerard Bos, Lotte Wieten Maastricht University Medical Center, Maastricht, Netherlands IN VIVO CRISPR/CAS9 SCREENING FOR THE IDENTIFICATION OF NOVEL PLAYERS IN LEUKEMIA IMMUNE ESCAPE Eleonora Draghi, Alessandro Migliara 2, Giacomo Oliveira, Arnolda Jakovija, Nice Turazzi, Antonella Antonelli, Barbara Camisa, Francesco Santaniello, Monica Volpin, Daniela Cesana, Eugenio Montini, Bernard Gentner 2, Attilio Bondanza, Chiara Bonini, Fabio Ciceri, Angelo Lombardo 2, Luca Vago San Raffaele Hospital Scientific Institute, Milan, Italy - 2 San Raffaele-Telethon Institute for Gene Therapy, Milan, Italy EXPLORING FCγRIIIA GENE VARIATION: NOVEL APPROACHES TO EXAMINE FULL-LENGTH GENE POLYMORPHISMS Timo I. Olieslagers, Niken M. Mahaweni, Ivan Rivas Olivares, Stefan Molenbroeck, Gerard M. Bos, Mathijs Groeneweg, Marcel G.J. Tilanus, Christina E.M. Voorter, Lotte Wieten Maastricht University Medical Center, Maastricht, Netherlands 22

23 JOINT EFI-AIBT Thursday 0 May 208 PARALLEL SESSIONS O29 O30 O3 O32 MOSAICI ROOM - PALAZZO CASINÒ (3 rd FLOOR) MULTIKINASES INHIBITOR IMPAIRING VASCULATURE FACILITATES THE IMMUNE RESPONSIVENESS AGAINST LEUKEMIA BY DECREASING THE POTENTIAL OF REGULATORY CELLS Emilia Jaskuła, Janusz Lange 2, Mariola Sedzimirska 2, Helena Pakos 2, Michalina Krydel 2, Jolanta Bochenska 2, Iwona Maszko-Wodzinska 2, Andrzej Lange L. Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences/ Lower Silesian Center for Cellular Transplantation with National Bone Marrow Donor Registry, Wroclaw, Poland - 2 Lower Silesian Center for Cellular Transplantation with National Bone Marrow Donor Registry, Wroclaw, Poland DONOR/RECIPIENT IL6 GENOTYPE IS NOT ASSOCIATED WITH SERUM PROFILE OF INFLAMMATION-ASSOCIATED MOLECULES IN PATIENTS AFTER ALLOGENEIC HAEMATOPOIETIC STEM CELL TRANSPLANTATION Frantisek Mrazek, Petra Schneiderova, Ludek Raida, Eva Kriegova, Adam Kuba, Martin Petrek, Zuzana Ambruzova Faculty of Medicine and Dentistry, Palacky University and University Hospital, Olomouc, Czech Republic FIRST PILOT STUDY ON THE EFFICACY OF INTRAVENOUS IMMUNOGLOBULINS (IVIG) IN BEHCET PATIENTS: IMPROVEMENT OF DISEASE ACTIVITY INDEX AND INFLAMMATORY MARKERS Martina Finocchi, Giacomo Emmi, Elena Silvestri, Annalisa De Silvestri 2, Carmine Tinelli 2 Cristina Capittini 2 Careggi University Hospital, University of Florence, Florence, Italy - 2 IRCCS Policlinico San Matteo Foundation, Pavia, Italy VACCINATION WITH A PNEUMOCOCCAL CONJUGATE VACCINE DOES NOT INDUCE HLA ANTIBODIES IN KIDNEY TRANSPLANT RECIPIENTS Monika Lindemann, Simon Heckel 2, Benjamin Wilde 3, Peter A. Horn, Falko M. Heinemann, Oliver Witzke 4 Institute for Transfusion Medicine, University Hospital, Essen, Germany - 2 Institute for Transfusion Medicine, Department of Infectious Diseases, Department of Nephrology, University Hospital, Essen, Germany - 3 Department of Nephrology, University Hospital, Essen, Germany - 4 Department of Infectious Diseases, University Hospital, Essen, Germany THURSDAY 23

24 ART AND SCIENCE: THE EVOLVING PICTURE VENICE LIDO, MAY 9-2, 208 Thursday 0 May 208 PARALLEL SESSIONS THURSDAY 0:20-:50 Oral Session 2: New Technologies and Bioinformatics Chairpersons: Emanuele Cozzi, Eric Spierings O7 O8 O9 O20 O2 MOSAICI 2 ROOM - PALAZZO CASINÒ (3 rd FLOOR) NEXT-GENERATION TARGET CAPTURE AND DIRECT LONG READ SEQUENCING OF THE MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) Johannes Dapprich, Oscar A. Pérez-Escobar 2, Sidonie Bellot 2, Jessica Rothe 3, Stefanie Köcher 3, Marion Nagy 3, Mehmet Tevfik Dorak 4, Stephen Rudd 5, Fabian Grunz 6, Nicolas Krezdorn 6, Klaus Hoffmeier 6 Generation Biotech, Lawrenceville, United States of America - 2 Royal Botanic Gardens Kew, Richmond, United Kingdom (Great Britain) - 3 Institute for Legal Medicine, Berlin, Germany - 4 Kingston University, London, United Kingdom (Great Britain) - 5 Oxford Nanopore Technologies, Oxford, United Kingdom (Great Britain) - 6 GenXPro, Frankfurt, Germany HIGH RESOLUTION HAPLOTYPE ANALYSES OF CLASSICAL HLA GENES IN FAMILIES FOR THE 7TH INTERNATIONAL HLA AND IMMUNOGENETICS WORKSHOP Kazutoyo Osoegawa, Lisa E. Creary 2, Kalyan Mallempati, Sridevi Gangavarapu, Steven J. Mack 3, Medhat Askar 4, Marcelo Fernandez Vina 2 Stanford Blood Center, Palo Alto, United States of America - 2 Stanford University School of Medicine, Palo Alto, United States of America - 3 Children s Hospital Oakland Research Institute, Oakland, United States of America - 4 Baylor University Medical Center, Dallas, United States of America IPD-MHC DATABASE: IMPROVING TOOLS FOR THE ANALYSIS OF THE MAJOR HISTOCOMPATIBILITY COMPLEX Giuseppe Maccari, James Robinson 2, Natasja G. de Groot 3, Nel Otting 3, Ronald E. Brontop 3, John A. Hammond 4, Steven GE. Marsh 2 The Pirbright Institute and Anthony Nolan, Guildford, United Kingdom (Great Britain) - 2 Anthony Nolan and UCL Cancer Institute, London, United Kingdom (Great Britain) - 3 Biomedical Primate Research Centre, Rijswijk, Netherlands - 4 The Pirbright Institute, Guildford, United Kingdom (Great Britain) IS NANOPORE SEQUENCING READY FOR PRIME TIME? ACCURATE HLA CLASS I GENOTYPING AND DETECTION OF NOVEL SEQUENCE VARIANTS BASED ON FULL GENE SEQUENCE ANALYSIS Vineeth Surendranath, Kathrin Lang, Alexander H. Schmidt 2, Gerhard Schöfl, Vinzenz Lange DKMS Life Science Lab, Dresden, Germany - 2 DKMS, Tübingen, Germany SIMULATING THROMBOCYTE TRANSFUSIONS TO INVESTIGATE THE ROLE OF T-HELPER AND B-CELL EPITOPES ON THE RISK FOR PLATELET REFRACTORINESS Kirsten Geneugelijk, Talitha de Hoop, Eric Borst, Eric Spierings University Medical Center Utrecht, Utrecht, Netherlands 24

25 JOINT EFI-AIBT Thursday 0 May 208 PARALLEL SESSIONS O22 O23 O24 MOSAICI 2 ROOM - PALAZZO CASINÒ (3 rd FLOOR) CONVERGING EVOLUTION LEADS TO NEAR MAXIMAL JUNCTION DIVERSITY THROUGH PARALLEL MECHANISMS IN B AND T CELL RECEPTORS Yoram Louzoun, Jennifer Benichou Bar Ilan University, Ramat Gan, Israel FULL-LENGTH HLA AND KIR ALLELE SEQUENCE CHARACTERIZATION WITH DR2S Steffen Klasberg, Kuntal Worah, Marie Günther, Kathrin Lang, Alexander H. Schmidt 2, Vinzenz Lange, Gerhard Schöfl DKMS Life Science Lab, Dresden, Germany - 2 DKMS, Tübingen, Germany COMPUTATIONAL SIMULATIONS DEMONSTRATE THE FEASIBILITY AND BENEFIT OF EPITOPE MATCHING FOR KIDNEY TRANSPLANTATION Matthias Niemann, Nils Lachmann 2, Oliver Staeck 2, Eric Spierings 3 PIRCHE AG, Berlin, Germany - 2 Charité - Universitätsmedizin Berlin, Berlin, Germany - 3 UMC Utrecht, Utrecht, Netherlands 2:00-3:00 Luncheon Session - GenDx 3:00-3:30 Lunch 3:30-4:30 Luncheon Session - Omixon THURSDAY 25

26 ART AND SCIENCE: THE EVOLVING PICTURE VENICE LIDO, MAY 9-2, 208 Thursday 0 May 208 PARALLEL SESSIONS THURSDAY 4:40-6:0 Oral Session 4: Haematopoietic Stem Cell Transplantation Chairpersons: Manuela Testi, Jean Villard O33 O34 O35 MOSAICI 2 ROOM - PALAZZO CASINÒ (3 rd FLOOR) BETTER HLA MATCHING AS REVEALED ONLY BY ULTRA-HIGH RESOLUTION HLA TYPING RESULTS IN SUPERIOR OVERALL SURVIVAL Neema P. Mayor, James D. Hayhurst 2, Thomas R. Turner, Richard M. Szydlo 3, Bronwen E. Shaw 4, Will P. Bultitude, Jex- Ray Sayno 2, Franco Tavarozzi 2, Katy Latham 2, Chloe Anthias 5, James Robinson, Henny Braund 2, Robert Danby 6, Julia Perry 7, Marie C. Wilson 8, Adrian J. Bloor 9, Andrew Clark 0, Stephen MacKinnon, David I. Marks 2, Antonio Pagliuca 3, Michael N. Potter 4, Victoria T. Potter 3, Nigel H. Russell 5, Kirsty J. Thomson, J. Alejandro Madrigal, Steven GE. Marsh Anthony Nolan Research Institute & UCL Cancer Institute, London, United Kingdom (Great Britain) - 2 Anthony Nolan Research Institute, London, United Kingdom (Great Britain) - 3 Anthony Nolan Research Institute & Imperial College, London, United Kingdom (Great Britain) - 4 CIBMTR and Froedtert & the Medical College of Wisconsin, Milwaukee, United States of America - 5 Anthony Nolan Research Institute & Royal Marsden NHS Foundation Trust, London, United Kingdom (Great Britain) - 6 Anthony Nolan Research Institute & Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, London, United Kingdom (Great Britain) - 7 British Society of Blood and Marrow Transplantation (BSBMT), London, United Kingdom (Great Britain) - 8 Anthony Nolan Research Institute & British Society of Blood and Marrow Transplantation (BSBMT), London, United Kingdom (Great Britain) - 9 The Christie NHS Foundation Trust, Manchester, United Kingdom (Great Britain) - 0 West of Scotland Cancer Centre, Gartnavel Hospital, Glasgow, United Kingdom (Great Britain) - University College London Hospitals, London, United Kingdom (Great Britain) - 2 University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom (Great Britain) - 3 Kings College Hospital, London, United Kingdom (Great Britain) - 4 Royal Marsden NHS Foundation Trust, Sutton, United Kingdom (Great Britain) - 5 Nottingham University Hospital, Nottingham, United Kingdom (Great Britain) INVESTIGATING THE RECONSTITUTION OF THE T LYMPHOCYTE REPERTOIRE BY HIGH THROUGHPUT SEQUENCING AT ONE YEAR FOLLOWING HAEMATOPOIETIC STEM CELL TRANSPLANTATION IN A LARGE COHORT OF PATIENTS FROM SWITZERLAND Stéphane Buhler, Florence Studer-Bettens, Carole Dantin, Sylvie Ferrari-Lacraz, Yves Chalandon, Jean Villard Geneva University Hospitals, Geneva, Switzerland DISSECTING GENETIC CONTROL OF HLA-DPB EXPRESSION AND ITS RELATION TO STRUCTURAL MISMATCH MODELS IN HEMATOPOIETIC STEM CELL TRANSPLANTATION Thuja Meurer, Esteban Arrieta Bolaños, Maximilian Metzing, Mona Langer 2, Peter van Balen 3, Frederick Falkenburg 3, Dietrich W. Beelen 4, Peter A. Horn 2, Katharina Fleischhauer, Pietro Crivello Institute for Experimental Cellular Therapy, University Hospital Essen, Essen, Germany - 2 Institute for Transfusion Medicine, University Hospital Essen, Essen, Germany - 3 Department of Hematology, Leiden University Medical Center, Leiden, Netherlands - 4 Department of Bone Marrow Transplantation, West German Cancer Center, University Hospital Essen, Essen, Germany 26

27 JOINT EFI-AIBT Thursday 0 May 208 PARALLEL SESSIONS O36 O37 O38 O39 O40 MOSAICI 2 ROOM - PALAZZO CASINÒ (3 rd FLOOR) HOW DONOR HLA MISMATCH, KIR-LIGAND MISMATCH AND NK CELL LICENSING MODELS AFFECT LEUKAEMIA RELAPSE IN HAEMATOPOIETIC STEM CELL TRANSPLANT RECIPIENTS Elzbieta Graczyk-Pol, Marta Rogatko-Koros, Klaudia Nestorowicz, Slawomir Gwozdowicz, Renata Mika-Witkowska, Daria Pawliczak, Marta Zubala, Joanna Dziopa, Urszula Szlendak, Agnieszka Witkowska, Agnieszka Tomaszewska, Barbara Nasilowska-Adamska, Andrzej Szczepinski, Michal Wojcik, Kazimierz Halaburda, Jacek Nowak Institute of Hematology and Transfusion Medicine, Warsaw, Poland INVESTIGATING THE IMPACT OF PATIENTS NON-SHARED HLA-C ALLOTYPE EXPRESSION LEVELS IN A 9/0 SINGLE HLA-C MISMATCHED UNRELATED HSCT SETTING USING AN HLA-C EXPRESSION PROXY MODEL Chrysanthi Tsamadou, Daniel Furst, Dietger Niederwieser 2, Donald Bunjes 3, Christine Neuchel, Martin Gramatzki 4, Renate Arnold 5, Eva Wagner 6, Hermann Einsele 7, Hubert Schrezenmeier, Joannis Mytilineos German Red Cross Blood Transfusion Service, Baden-Wuerttemberg Hessen, Ulm, Germany and Institute of Transfusion Medicine, University of Ulm, Ulm, Germany - 2 University of Leipzig, Leipzig, Germany - 3 University of Ulm, Ulm, Germany - 4 University of Kiel, Kiel, Germany - 5 Charité Campus Virchow Berlin, Ulm, Germany - 6 Johannes Gutenberg-University Mainz, Mainz, Germany - 7 University Hospital Würzburg, Würzburg, Germany MICRORNA EXPRESSION LEVELS IN CUTANEOUS ACUTE GRAFT-VERSUS HOST DISEASE Sadaf Atarod, Louis A. Bibby 2, Jean Norden 2, Anne Janin 3, Philippe Ratajczak 3, Clare Lendrem 2, Kim F. Pearce 2, Xiao-nong Wang 2, Steven O Reilly 4, Jacob M. Van Laar 5, Matthew Collin 2, Anne M. Dickinson 2, Rachel E. Crossland 2 Boston University and Boston Medical Center, Boston, United States of America - 2 Newcastle University, Newcastle upon Tyne, United Kingdom (Great Britain) - 3 Université Paris Diderot, Paris, France - 4 Northumbria University, Newcastle upon Tyne, United Kingdom (Great Britain) - 5 Utrecht University, Utrecht, Netherlands SINGLE HAPLOTYPE ADMIXTURE MODELS USING LARGE SCALE HLA GENOTYPES TO REPRODUCE HUMAN ADMIXTURE Yoram Louzoun, Alexandra Litniski, Abeer Madbouly 2, Michael Halagan 2, Martin Maiers 3 Bar Ilan University, Ramat Gan, Israel - 2 NMDP, Minneapolis, United States of America - 3 National Marrow Donor Program, Minneapolis, MN, United States of America QUANTITATIVE PCR-BASED CHIMERISM MONITORING IN BONE MARROW OR PERIPHERAL BLOOD TO PREDICT LEUKAEMIA RELAPSE IN HIGH-RISK PATIENTS: FINAL RESULTS OF THE KIM-PB PROSPECTIVE STUDY Valentina Gambacorta, Riccardo Parolini, Elisabetta Xue, Raffaella Greco, Evelien Bouwmans 2, Cristina Toffalori, Fabio Giglio, Andrea Assanelli, Maria Teresa Lupo Stanghellini, Alessandro Ambrosi 3, Wietse Mulder 2, Consuelo Corti, Jacopo Peccatori, Fabio Ciceri, Luca Vago San Raffaele Scientific Institute, Milano, Italy - 2 GenDx, Utrecht, Netherlands - 3 University Vita-Salute San Raffaele, Milano, Italy THURSDAY 27

28 ART AND SCIENCE: THE EVOLVING PICTURE VENICE LIDO, MAY 9-2, 208 Thursday 0 May 208 PARALLEL SESSIONS THURSDAY PERLA ROOM - PALAZZO CASINÒ ( st FLOOR) 0:20-:50 Teaching Session How NGS technology is changing the way of HLA typing Joannis Mytilineos, Sarah Patricia Peacock The whole gene: Application and implementation of whole gene sequencing in the clinical lab Katy Latham NGS in a Transplant Center: a French experience Béatrice Bardy Sequencing with nanopores: current status and near future potential Vineeth Surendranath General discussion & close 2:00-3:00 Luncheon Session - One Lambda 3:00-3:30 Lunch 28

29 JOINT EFI-AIBT Thursday 0 May 208 PARALLEL SESSIONS PERLA ROOM - PALAZZO CASINÒ ( st FLOOR) 4:40-6:0 Teaching Session 2 Clinical impact of de-novo HLA antibodies in solid organ transplantation Antonina Piazza, David Turner The clinical relevance of de novo HLA antibodies in renal transplantation Antonina Piazza The clinical relevance of de novo HLA antibodies in heart transplantation Martin Howell The clinical relevance of de novo HLA antibodies in pancreas and islet transplantation David Turner Q&A THURSDAY 6:0-6:30 Coffee break & Poster viewing PALAZZO CASINÒ 29

30 ART AND SCIENCE: THE EVOLVING PICTURE VENICE LIDO, MAY 9-2, 208 Thursday 0 May 208 PLENARY SESSION 2 Solid Organ Transplantation Chairpersons: Antonio Amoroso, Joannis Mytilineos AUDITORIUM - PALAZZO CINEMA 6:30-7:00 T regulatory cell based therapy in promoting tolerance solid organ transplantation Giovanna Lombardi 7:00-7:30 Desensitization in SOT Christophe M.F. Legendre 7:30-8:00 Novel Biomarkers for allograft rejection in SOT Minnie M. Sarwal THURSDAY 8:00-9:30 Poster Session (Wine&Cheese) PALAZZO DEL CASINÒ (3 rd FLOOR) 30

31 JOINT EFI-AIBT Friday May 208 PLENARY SESSION 3 HSCT Current clinical perspectives Chairpersons: Luca Vago, Lotte Wieten AUDITORIUM - PALAZZO CINEMA 8:30-9:00 Haplo settings or Impact of non shared haplotype on haplotransplant Leonido Luznik 9:00-9:30 Adoptive Immunotherapies in HSCT Chiara Bonini 9:30-0:00 Tregs in HSCT Silvia Gregori 0:00-0:20 Coffee break & Poster viewing PALAZZO CASINÒ 0:20-:50 Oral Session 5: Solid Organ Transplantation Chairpersons: Franco Papola, Dave L. Roelen O4 O42 MOSAICI ROOM - PALAZZO CASINÒ (3 rd FLOOR) A NEW TOOL FOR QUANTIFICATION OF THE DONOR HLA-SPECIFIC MEMORY B CELL REPERTOIRE IN IMMUNIZED PATIENTS Gonca E. Karahan, Yvonne J.H. de Vaal, Juliette Krop, Caroline Wehmeier, Dave L. Roelen, Frans H.J. Claas, Sebastiaan Heidt Leiden University Medical Center, Leiden, Netherlands ROLE OF HLA-E-RESTRICTED CD8+ T CELLS IN TRANSPLANTATION Gabriella Pietra, Selene Ottonello, Irene Cossu 2, Lucy C. Sullivan 3, Michela Falco 4, Maria Christina Mingari, Lorenzo Moretta 5 University of Genova, Genova, Italy - 2 IRCCS Ospedale Policlinico San Martino, Genova, Italy - 3 University of Melbourne, Melbourne, Australia - 4 Laboratory of Clinical and Experimental Immunology, Giannina Gaslini Institute, Genova, Italy - 5 Ospedale Pedriatico Bambino Gesù, Roma, Italy FRIDAY 3

32 ART AND SCIENCE: THE EVOLVING PICTURE VENICE LIDO, MAY 9-2, 208 Friday May 208 MOSAICI ROOM - PALAZZO CASINÒ (3 rd FLOOR) FRIDAY O43 O44 O45 O46 O47 O48 ENDOTHELIAL-EPITHELIAL-RELATED TRANSCRIPTIONAL LEVELS IN ACUTE REJECTION BIOPSIES OF KIDNEY TRANSPLANT RECIPIENTS ARE PREDICTIVE FOR A WORSE RESPONSE TO STEROID TREATMENT Jianxin Yang, Marijke J. Spruyt-Gerritse, Darius Soonawala, Geert W. Haasnoot, Hans W. de Fijter, Marlies E.J. Reinders, Marian C. Clahsen 2, Frans H.J. Claas, Michael Eikmans Leiden University Medical Center, Leiden, Netherlands - 2 Erasmus Medical Center, Rotterdam, Netherlands KIDNEY TRANSPLANTED PATIENTS WITH OPERATIONAL TOLERANCE HAVE INCREASED FREQUENCIES OF CD9+CDD+CD5+ SUPPRESSOR B CELLS AND HAVE A POSITIVE CORRELATION WITH THE PERCENTAGE OF TOTAL B CELLS Cristian M. Alvarez, Christian Morath 2, Marlon Castrillon, Daniel Alzate, Gerhard Opelz 2, Martin Zeier 2, Caner Süsal 2 Universidad de Antioquia, Medellin, Colombia - 2 University of Heidelberg, Heidelberg, Germany HLA EPITOPE MATCHING OF KIDNEY TRANSPLANTS PREDICTS ANTIBODY- AND CELL- MEDIATED REJECTION Nils Lachmann, Oliver Staeck, Matthias Niemann 2, Klemens Budde, E. Spierings 3, Constanze Schönemann Charité - Universitätsmedizin Berlin, Berlin, Germany - 2 PIRCHE AG, Berlin, Germany - 3 University Medical Center Utrecht, Utrecht, Netherlands STUDY OF IMMUNOLOGICAL AND IMMUNOGENIC RISK FACTORS FOR BKV REPLICATION AFTER RENAL TRANSPLANTATION Snezhina Mihaylova, Atanaska Georgieva 2, Yana Krasteva 2, Anastasya Mihaylova, Tsvetelin Lukanov 2, Valentina Atanasova 2, Luisa Hristova 2, Emil Paskalev, Elissaveta Naumova Medical University Sofia, University Hospital Alexandrovska, Sofia, Bulgaria - 2 University Hospital Alexandrovska, Sofia, Bulgaria DIFFERENCES FOR T-CELLS SUBTYPES IN ASPIRATION BIOPSIES OF KIDNEY TRANSPLANT PATIENTS UNDER POLYCLONAL AND MONOCLONAL IMMUNOSUPPRESSIVE TREATMENTS Maria Paula DP. Xavier, Maria Conceição Magalhães 2, Susana Sampaio-Norton 3, Tiago Guimarães 2, José Gerardo Oliveira 4 Instituto Português do Sangue e da Transplantação, Porto, Portugal - 2 Centro Hospitalar S. João, Serviço Patologia Clínica, Porto, Portugal - 3 Hospital S. João, Serviço Nefrologia, Porto, Portugal - 4 Faculdade Medicina Porto, Hospital S. João, Porto, Portugal IMPACT OF HLA-E*0:03 ALLELE CARRIER STATUS AND NKG2C ALLELE DELETION ON THE RISK OF CMV INFECTION AFTER RENAL TRANSPLANTATION Hana Guberina, Fabiola da Silva Nardi, Rafael Tomoya Michita, Sebastian Dolff, Anja Gäckler, Falko M. Heinemann, Benjamin Wilde, Mirko Trilling, Peter A. Horn, Andreas Kribben, Oliver Witzke, Vera Rebmann University Hospital Essen, University Duisburg-Essen, Essen, Germany 2:00-3:00 Luncheon Session - Bag Healthcare 3:00-3:30 Lunch 32

33 JOINT EFI-AIBT Friday May 208 MOSAICI ROOM - PALAZZO CASINÒ (3 rd FLOOR) 4:40-6:0 Oral Session 7: Reproduction, Autoimmunity, Infection & Cancer Chairpersons: Andrea Bontadini, Antonio Martinho O57 O58 O59 O60 AN ALTERNATIVELY SPLICED ISOFORM OF THE HUMAN LEUKOCYTE ANTIGEN-DR ALPHA CHAIN IS ASSOCIATED WITH THE MULTIPLE SCLEROSIS RISK ALLELE HLA-DRB*5:0 Vincent Damotte, Alessandro Didonna, Maneesh K. Misra, Noriko Isobe, Ravi Dandekar, Ashley H. Beecham 2, Stacy Cailler, Adam Santaniello, Jacob L. McCauley 2, Steven L. Hauser, Jorge R. Oksenberg, Jill A. Hollenbach University of California, San Francisco, San Francisco, United States of America - 2 University of Miami, Miami, United States of America HELLP SYNDROME IS ASSOCIATED WITH MHC GENES IN A FINNISH POPULATION A. Inkeri Lokki, Jenni Heikkinen-Eloranta 2, Juha Sinisalo 2, Hannele Laivuori 3, Marja-Liisa Lokki University of Helsinki, Helsinki, Finland - 2 University of Helsinki and Helsinki University Hospital, Helsinki, Finland - 3 University of Tampere, Tampere, Finland EXPRESSION QTLS WITH OPPOSING EFFECTS ON HLA-DR AND -DQ GENES ARE ASSOCIATED WITH AUTOIMMUNE DISORDERS: EVIDENCE FOR MIXED ISOTYPE HETERODIMER FORMATION? Sandeep K. Singh, Johannes Dapprich 2, Jacob L. McCauley 3, Mehmet Tevfik Dorak 4 Ohio State University, Columbus, OH, United States of America - 2 Generation Biotech, Lawrenceville, NJ, United States of America - 3 University of Miami, John P. Hussman Institute for Human Genomics, Miami, FL, United States of America - 4 Kingston University London, Kingston, United Kingdom (Great Britain) HLA-DRB*09:0 IS ASSOCIATED WITH A SEVERE ASTHMA OUTCOME IN THE CONSORTIUM ON ASTHMA AMONG AFRICAN-ANCESTRY POPULATIONS IN THE AMERICAS (CAAPA) Nicolas Vince, Sophie Limou 2, Michelle Daya 3, Nicholas Rafaels 3, Jill Hollenbach 4, Antoine Lizée 4, Estelle Geffard, Alexandre Walencik 5, Maria Pino-Yanes 6, Steven Salzberg 7, Daehwan Kim 7, Harold Watson 8, Leslie Lange 3, James Wilson 9, Terri Beaty 7, Margaret Taub 7, Ingo Ruczinski 7, Rasika Mathias 7, (CAAPA) Consortium on Asthma among African-ancestry Populations in the Americas 7, Kathleen Barnes 3, Dara Torgerson 4, Pierre-Antoine Gourraud 0 INSERM, Université de Nantes, Nantes, France - 2 INSERM, Université de Nantes, Ecole Centrale de Nantes, Nantes, France - 3 University of Colorado, Aurora, CO, United States of America - 4 University of California San Francisco, San Francisco, CA, United States of America - 5 EFS Centre - Pays de la Loire, Nantes, France - 6 Universidad de La Laguna, Santa Cruz de Tenerife, Spain - 7 Johns Hopkins University, Baltimore, MD, United States of America - 8 The University of the West Indies, Queen Elizabeth Hospital, Bridgetown, Barbados - 9 University of Mississippi Medical Center, Jackson, MS, United States of America - 0 INSERM, Université de Nantes, CHU de Nantes, Nantes, France FRIDAY 33

34 ART AND SCIENCE: THE EVOLVING PICTURE VENICE LIDO, MAY 9-2, 208 Friday May 208 MOSAICI ROOM - PALAZZO CASINÒ (3 rd FLOOR) FRIDAY O6 O62 O63 O64 NEXT GENERATION SEQUENCING OF BTNL2 REVEALS NOVEL ASSOCIATIONS WITH ACUTE CORONARY SYNDROME IN FINNISH POPULATION Marja Marchesani, Juha Sinisalo 2, Veikko Salomaa 3, Markus Perola 4, Markku S. Nieminen 5, Steven J. Mack 6, Marja-Liisa Lokki University of Helsinki, Helsinki, Finland - 2 Helsinki University Hospital, Helsinki, Finland - 3 National Institute for Health and Welfare, Helsinki, Finland - 4 National Institute for Health and Welfare (THL), Helsinki, Finland - 5 Helsinki University Central Hospital, Helsinki, Finland - 6 Children s Hospital Oakland Research Institute, United States of America MACROPHAGE MIGRATION INHIBITORY FACTOR AND D-DOPACHROME TAUTOMERASE ARE POTENTIAL DISEASE SEVERITY MODIFIERS IN MALE MULTIPLE SCLEROSIS SUBJECTS Gil Benedek, Halina Offner 2, Jorge R. Oksenberg 3, Dennis Bourdette 2, Richard Bucala 4, Arthur A. Vandenbark 2 Hadassah Medical Center, Jerusalem, Israel - 2 Oregon Health & Science University, Portland, Oregon, United States of America - 3 University of California, San Francisco, San Francisco, United States of America - 4 Yale School of Medicine, New Haven, United States of America FUNCTIONAL ANNOTATION OF THE CLUSTER OF SCHIZOPHRENIA RISK MARKERS IN THE EXTENDED HLA CLASS I REGION Sandeep K. Singh, Johannes Dapprich 2, Mehmet Tevfik Dorak 3 Ohio State University, Columbus, OH, United States of America - 2 Generation Biotech, Lawrenceville, NJ, United States of America - 3 Kingston University London, Kingston, United Kingdom (Great Britain) ASSOCIATION OF MICA POLYMORPHISM WITH MICA SERUM LEVELS AND CLINICAL OUTCOME OF ANTI-TNF THERAPY IN PATIENTS WITH RHEUMATOID ARTHRITIS Milena Iwaszko, Jerzy Świerkot 2, Marta Dratwa, Barbara Wysoczańska, Lucyna Korman 2, Katarzyna Kolossa 3, Sławomir Jeka 3, Piotr Wiland 2, Katarzyna Bogunia-Kubik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland - 2 Wrocław Medical University, Wrocław, Poland - 3 Hospital University Number 2 Jana Biziela, Bydgoszcz, Poland 34

35 JOINT EFI-AIBT Friday May 208 0:20-:50 Oral Session 6: NK and Miscellaneous Chairpersons: Benedetta Mazzi, Caner Süsal O49 O50 O5 O52 O53 O54 MOSAICI 2 ROOM - PALAZZO CASINÒ (3 rd FLOOR) IMPACT OF KIR ALLELE POLYMORPHISM ON THE STRUCTURE AND THE FUNCTION OF KIR2D NK CELL REPERTOIRE Katia Gagne, Bercelin Maniagou 2, Léa Dubreuil 2, Gaelle David 2, Nolwenn Legrand 2, Catherine Willem 2, Christelle Retiere 2 Blood Bank EFS; CRCINA; Labex Transplantex, Nantes, France - 2 Blood Bank EFS; CRCINA; Nantes, France THE ROLE OF T CELL RECEPTOR CROSS-REACTIVITY IN HUMAN DISEASES Nicole Mifsud, Louise Rowntree, Lloyd D Orsogna 2, Heleen van den Heuvel 3, Frans Claas 4, Patricia Illing, Stephanie Gras, Tom Kotsimbos 5, Anthony Purcell Monash University, Clayton, Australia - 2 Fiona Stanley Hospital, Perth, Australia - 3 Leiden University Medical Centre/Monash University, Leiden, Netherlands - 4 Leiden University Medical Centre, Leiden, Netherlands - 5 The Alfred Hospital/Monash University, Melbourne, Australia THE GENETIC IMBALANCE AMONG HLA LIGANDS FOR INHIBITORY KIR3D RECEPTORS IN KAWASAKI CHILDREN: CLUES FOR ETIOPATHOGENESIS Cristina Capittini, Annalisa De Silvestri, Grazia Bossi, Savina Mannarino, Annamaria A. Pasi, Carmine Tinelli, Miryam Martinetti IRCCS Policlinico San Matteo Foundation, Pavia, Italy KIR HAPLOTYPES DEFINED BY THEIR TRANSCRIPTOMES Jesse Bruijnesteijn, Marit K. H. Van der Wiel, Wendy Swelsen 2, Nel Otting 3, Annemiek J. M. de Vos-Rouweler 3, Diënne Elferink 4, Gaby G.M. Doxiadis 3, Neubury M. Lardy 2, Natasja G. De Groot 3, Ronald E. Bontrop 3 BPRC, Rijswijk, Netherlands - 2 Sanquin, Amsterdam, Netherlands - 3 Biomedical Primate Research Centre, Rijswijk, Netherlands - 4 LUMC, Leiden, Netherlands FUNCTIONAL ANALYSIS OF SOLUBLE NKG2D LIGAND EXPRESSION IN UMBILICAL CORD BLOOD PLASMA REVEALS ACTIVATING POTENTIAL OF SOLUBLE MICA-29VAL VARIANTS Steven T. Cox, Robert Danby, Diana Hernandez, Alejandro Madrigal, Aurore Saudemont Anthony Nolan Research Institute, London, United Kingdom (Great Britain) VITREOUS CRYOPRESERVATION OF HLA-MATCHED VASCULAR GRAFTS UTILIZING THE DECELLULARIZED HUMAN UMBILICAL ARTERY Panagiotis Mallis, Efstathios Michalopoulos, Michalis Katsimpoulas 2, Amalia Dinou, Aggeliki Papapanagiotou 3, Maria Spyropoulou-Vlachou 4, Catherine Stavropoulos-Giokas Hellenic Cord Blood Bank-Biomedical Research Foundation Of the Academy of Athens, Athens, Greece - 2 Biomedical Research Foundation Of the Academy of Athens, Athens, Greece - 3 National and Kapodistrian University of Athens, Athens, Greece - 4 Alexandra General Hospital of Athens, Athens, Greece FRIDAY 35

36 ART AND SCIENCE: THE EVOLVING PICTURE VENICE LIDO, MAY 9-2, 208 Friday May 208 MOSAICI 2 ROOM - PALAZZO CASINÒ (3 rd FLOOR) O55 O56 GENE EXPRESSION PROFILING REVEALS THE MOLECULAR SIGNATURE OF SEVERE CARBAMAZEPINE-INDUCED HYPERSENSITIVITY REACTIONS Nicole Mifsud, Alison Anderson 2, Patricia Illing, Patrick Kwan 2, Anthony Purcell Monash University, Clayton, Australia - 2 Royal Melbourne Hospital/University of Melbourne, Parkville, Australia HLA-G SELECTS PEPTIDES TISSUE SPECIFIC AND DISPLAYS EXCEPTIONAL TARGETS FOR IMMUNE EVASION Alexander A. Celik, Gwendolin S. Simper, Trevor Huyton 2, Wiebke Hiemisch, Rainer Blasczyk, Christina Bade-Doeding Hannover Medical School, Hannover, Germany - 2 Max Planck Institute, Göttingen, Germany 3:00-3:30 Lunch 3:30-4:30 Luncheon Session - Histogenetics FRIDAY PERLA ROOM - PALAZZO CASINÒ ( st FLOOR) 0:20-:50 Teaching Session 3 Tools for a successful HSCT: evaluation of HLA allele frequencies, anti-hla antibodies, structural and expression models for permissive mismatches Marcelo A. Fernández-Viña, Katharina Fleischhauer Allele and haplotype frequencies: How variation affects donor searches Anti-HLA antibodies: Role of DSA in HLA mismatched transplantation Coding and non-coding HLA variation: Relationship between T-cell epitopes and HLA expression levels for permissive mismatches in HSCT 2:00-3:00 Luncheon Session - One Lambda 3:00-3:30 Lunch 36

37 JOINT EFI-AIBT Friday May 208 PERLA ROOM - PALAZZO CASINÒ ( st FLOOR) 4:40-6:0 Teaching Session 4 How to prepare for an inspection: demonstrating how quality standards are Met Andrea Harmer, Luca Mascaretti Presenters: Milena Ivanova (Bulgaria), Christien Voorter (Netherlands) Preparing for Packet A and Packet C inspection Common deficiencies How to meet molecular testing and main quality management standards Use of the accreditation software Q&A and best practices 6:0-6:30 Coffee break & Poster viewing PALAZZO CASINÒ FRIDAY 37

38 ART AND SCIENCE: THE EVOLVING PICTURE VENICE LIDO, MAY 9-2, 208 Friday May 208 SPECIAL JOINT SESSION WMDA and EFI Chairpersons: Lydia Foeken, Elissaveta Naumova, Nicoletta Sacchi AUDITORIUM - PALAZZO CINEMA 4:40-5:0 Past, Present and future of unrelated Donor registries Lydia Foeken 5:0-5:40 Pharma-economics of CB banking in the haplo era Sergio Luis Querol-Giner 5:40-6:0 How to choose the best unrelated HSC donor? Carolyn Katovich Hurley FRIDAY PLENARY SESSION 4 Immunogenetics beyond HLA Chairpersons: Marcel G.J. Tilanus, John Trowsdale 6:30-7:00 Immunogenetics in Autoimmunity Francesco Cucca 7:00-7:30 Epigenetic reprogramming in HSCT Angelo Lombardo 7:30-8:00 GWAS in Multiple Sclerosis Stephen James Sawcer AUDITORIUM - PALAZZO CINEMA 8:00-9:30 EFI General Assembly PERLA ROOM - PALAZZO CASINÒ ( st FLOOR) 38

39 JOINT EFI-AIBT Saturday 2 May 208 8:30-0:00 Best Abstract Session Chairpersons: Katharina Fleischhauer, Luca Mascaretti O O2 O3 O4 O5 AUDITORIUM - PALAZZO CINEMA THE ENIGMA OF HLA-MEDIATED ADVERSE DRUG REACTIONS: EPOXIDE BUT NOT CARBAMAZEPINE INDUCES THE BINDING OF HAPTENATED PEPTIDES TO HLA-B*5:02 Gwendolin S. Simper, Alexander A. Celik, Gia-Gia T. Hò, Trevor Huyton 2, Joachim Kuhn 3, Rainer Blasczyk, Christina Bade-Doeding Hannover Medical School, Hannover, Germany - 2 Max Planck Institute, Göttingen, Germany - 3 Heart and Diabetes Center North Rhine-Westphalia, Bad Oeynhausen, Germany IMMUNITY ON A KNIFES EDGE: SELF/NON-SELF DISCRIMINATION AND THE CO- EXPRESSION OF NATURAL KILLER CELL RECEPTORS FINELY TUNES T CELL RECEPTOR AFFINITY AND FUNCTION Lucy C. Sullivan, Christopher M. Harpur, Thi H.O. Nguyen, Abbie R. Kanagarajah, Jacqueline M.L. Widjaja, Gabriella Pietra 2, Katherine Kedzierska, Karl-Johan Malmberg 3, Andrew G. Brooks University of Melbourne, Melbourne, Australia - 2 University of Genoa, Genoa, Italy - 3 Institute for Cancer Research, Oslo University Hospital, Oslo, Norway INVISIBLE ORGANS MADE BY GENETIC ENGINEERING TO TURN OFF MHC PRIOR TO ALLOGENEIC TRANSPLANTATION PREVENT A PRO-INFLAMMATORY CYTOKINE RESPONSE IN THE RECIPIENT Constanca Figueiredo, Marco Carvalho-Oliveira, Chen Chen-Wacker, Klaus Höffler, Marc Kühnel, Katharina Jansson, Axel Haverich, Gregor Warnecke, Rainer Blasczyk Hannover Medical School, Hannover, Germany THE ALLOTYPIC ARCHITECTURE OF HLA-B57 ALLOTYPES ALTERS PEPTIDE CONFORMATION TO REGULATE INHIBITION OF NK CELL ACTIVATION THROUGH KIR3DL Andrew G. Brooks, Philippa M. Saunders, Philip Pymm 2, Jacqueline ML. Widjaja, Jie Lin, Jamie Rossjohn 2, Julian P. Vivian 2 Peter Doherty Institute, University of Melbourne, Melbourne, Australia - 2 Monash University, Clayton, Australia EPIGENOME-WIDE ASSOCIATION STUDY REVEALS IMMUNOGENETIC TARGETS OF DNA METHYLATION MODIFICATION BY HIV- Kevin Hoang, George Nelson 2, Elisabeth Binns-Roemer 2, Nicolas Vince, Pierre-Antoine Gourraud 3, James J. Goedert 4, Cheryl Winkler 2, Sophie Limou 5 INSERM, Université de Nantes, Nantes, France - 2 Frederick National Laboratory, Frederick, MD, United States of America - 3 INSERM, Université de Nantes, CHU de Nantes, Nantes, France - 4 NIH/NCI, Bethesda, MD, United States of America - 5 INSERM, Université de Nantes, Ecole Centrale de Nantes, Nantes, France SATURDAY 39

40 ART AND SCIENCE: THE EVOLVING PICTURE VENICE LIDO, MAY 9-2, 208 Saturday 2 May 208 AUDITORIUM - PALAZZO CINEMA O6 O7 EXPLOITING CUTTING-EDGE TECHNOLOGIES TO ANALYZE LOSS OF HLA IN A GLOBAL MULTICENTRIC COHORT OF POST-TRANSPLANTATION RELAPSES: PRELIMINARY RESULTS FROM THE HLALOSS COLLABORATIVE STUDY Luca Vago, Cristina Toffalori, Ahci Müberra 2, Vinzenz Lange 3, Kathrin Lange 3, Sonia Todaro, Karin Stempelmann 2, Andreas Heinold 2, Friedrich Stölzel 4, Miguel Waterhouse 5, Rainer Claus 5, Ketevan Gendzekhadze 6, Masahiro Onozawa 7, Raynier Devillier 8, Ruoping Tang 9, Maayan Ulman 0, Dejan Lazarevic, Maria Teresa Lupo Stanghellini, Jacopo Peccatori, Nina K. Steckel 2, Peter A. Horn 2, Alessandra Picardi, Sara Manetta 2, Jose L. Pinana 3, Jaimie Sanz 3, Brian Schaffer 4, William Arcese, Guillermo Sanz 3, Benedetto Bruno 2, Massimo Pini 5, Guido Kobbe 6, Katharine C. Hsu 4, Monzr Al Malki 6, Takanori Teshima 7, Nicolaus Kroeger 7, Jurgen Finke 5, Arnon Nagler 0, Didier Blaise 8, Mohamad Mohty 9, Martin Bornhauser 4, Dietrich W. Beelen 2, Alexander Schmidt 3, Fabio Ciceri, Katharina Fleischhauer 2 San Raffaele Scientific Institute, Milano, Italy - 2 Essen University Hospital, Essen, Germany - 3 DKMS Life Science Lab, Dresden, Germany - 4 Technical University Dresden, Medical Clinic and Policlinic I, Dresden, Germany - 5 University Medical Center Freiburg, Freiburg, Germany - 6 City of Hope National Medical Center, Duarte, CA, United States of America - 7 Hokkaido University, Faculty of Medicine, Sapporo, Japan - 8 Institut Paoli-Calmettes, Marseille, France - 9 Hopital Saint Antoine AP-HP, Paris, France - 0 Chaim Sheba Medical Center, Tel-Hashomer and Tel-Aviv University, Tel Aviv, Israel - Tor Vergata University of Rome - Regional Transplant Center of Lazio, Roma, Italy - 2 A.O.U. Città della Salute e della Scienza di Torino, Torino, Italy - 3 Hospital Universitari i Politècnic La Fe, Valencia, Spain - 4 Memorial Sloan Kettering Cancer Center, New York, NY, United States of America - 5 A.O. SS Antonio e Biagio e C. Arrigo, Alessandria, Italy - 6 Heinrich-Heine University, Dusseldorf, Germany - 7 University Hospital Eppendorf, Hamburg, Germany UNRAVELLING DYNAMIC CHANGES IN THE MATERNAL IMMUNE COMPARTMENT AT THE MATERNAL-FETAL INTERFACE DURING PREGNANCY BY MASS CYTOMETRY Anita van der Zwan, Vincent van Unen, Thomas Höllt 2, Hanneke J.M. Kapsenberg, Marie-Louise P. van der Hoorn, Merve Uyar-Mercankaya, Susana M. Chuva de Sousa Lopes, Frits Koning, Frans H.J. Claas, Sebastiaan Heidt Leiden University Medical Center, Leiden, Netherlands - 2 Delft University of Technology, Delft, Netherlands SATURDAY O8 LOSS OF HLA-A IN ACUTE MYELOID LEUKEMIA TRANSMITTED BY THE DONOR TO LIVER AND KIDNEY GRAFT RECIPIENTS Luigi Marchionni, Anna Serra 2, Federico Genzano Besso 3, Silvia Deaglio 2, Piero Stratta 4, Monica Berrino 3, Francisco Lobo Pereira, Aleksei Stupniko, Gianluca Gaidano 4, Benedetto Bruno 2, Giuseppe Saglio 2, Antonio Amoroso 4 Johns Hopkins University, Baltimore, United States of America - 2 University of Turin, Turin, Italy - 3 Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, Presidio Molinette, Torino, Italy - 4 University of Eastern Piedomont, Novara, Italy 0:00-0:30 7 th and 8 th IHW reports The 7 th International HLA & Immunogenetics Workshop 207 Marcelo A. Fernández-Viña The 8 th International HLA & Immunogenetics Workshop 202 Eric Spierings 0:30-0:50 Coffee break 40