CURRICULUM VITA Didem Vardar-Ulu. Wellesley College Tel: (781)

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1 CURRICULUM VITA Didem Vardar-Ulu Wellesley College Tel: (781) Department of Chemistry Central Street Wellesley, MA EDUCATION and PROFESSIONAL PREPARATION: Institution Major/Area Degree and Year Bilkent University (Ankara, Turkey) Physics B.S., 1995 Boston University School of Medicine Biophysics Ph.D., 2001 Harvard Medical School/Beth Isreal-Deaconess Homeostasis Post-doc, &Thrombosis Harvard Medical School/Brigham&Women s Hos. Pathology Post-doc, APPOINTMENTS AND PROFESSIONAL EXPERIENCE Assistant Professor: Wellesley College, Chemistry Department, 07/2006- present Visiting Scholar: Blacklow Laboratory, Department of Pathology, Harvard Medical School/Brigham and Women s Hospital July Postdoctoral Fellow: Dr. Stephen C. Blacklow, Brigham and Women s Hospital/Harvard Medical School 03/ Research on the structure and biochemistry of the Notch Receptors. Postdoctoral Fellow: Drs. Barbara and Bruce Furie, Beth Isreal-Deaconess Medical Center/ Harvard Medical School, Center for Hemostasis and Thrombosis Research, 01/ /2002 Research on the biophysical and biochemical characterization of -carboxylated proteins. Selected Participant: European Molecular Biology Laboratory, Heidelberg, Germany, 09/ nd EMBO Practical Course on Structure Determination of cromolecules by Solution NMR Doctoral Research: Dr. C. James McKnight, Boston University School of Medicine, Department of Physiology and Biophysics 09/ /2001 Research on biophysical and biochemical characterization of headpiece domains and their functional implications Undergraduate Research Assistant: Dr. Atilla Aydinli, Dr. Sefik Suzer, Bilkent University, Turkey, Advanced Research Laboratory for Semiconductor and Device Physics, 07/ /1995 Research on the photoluminescence and Raman Spectroscopy of silicon oxide and nitride thin films. Research on the FTIR spectroscopy of polystyrene. Summer Research Student: Dr. Wolf Weyrich, Physical Chemistry Konstanz University, Germany, Summer 1994 Research on Compton scattering in crystals. Intern Research Student, Dr. Michel Koch, Dr. Zehra Sayers, European Molecular Biology Laboratory (EMBL), Hamburg Outstation, Germany Summer 1993 Research on PCR amplification of control sequences for the Cu-metallothionine gene from yeast chromosomal DNA

2 TEACHING EXPERIENCE: Wellesley Courses Taught: (Wellesley College, Wellesley, MA) Introduction to Biochemistry, CHEM222 both lecture and laboratory Biochemistry I, CHEM221 Biochemistry II, CHEM328 Chemical Analysis and Equilibrium, CHEM205 Chemistry of Food and Beauty Products, CHEM Instructor: Protein Purification, Biotechnology Certificate Program at Boston University Designed and implemented a hands-on applications based curriculum (lecture and lab) to teach the basic principles and the state of the art advances in protein purification to a professional audience working in biomedical industry Conference Leader: Harvard Medical School, Pharmacology Course for the medical students Directed the weekly discussion series and graded the exam papers together with the other conference leaders for the mandatory pharmacology course for the medical students at the Harvard Medical School Certified MCAT Physics and GRE teacher: The Princeton Review, HONORS and AWARDS NIH AREA (R15): 07/ /2013 Cottrell College Science Award, Research Corporation: 07/ /2011 Biology Scholars Research Residency Program ( Cohort): 07/ /2013 The Camille & Dreyfus Foundation Faculty Start-up Award: 07/ /2012 Wellesley College Faculty Award: 01/01/08 12/31/2008 Staley Small Grant, Wellesley College: 01/01/07 06/30/08 Wellesley College Faculty Award: 01/01/07 12/31/2007 Wellesley College Educational Research and Development General Grant: 07/01/08-06/30/ ASBMB Undergraduate Faculty Travel Award: April 2010 HHMI Curriculum Development Award: 07/ /2010 American Cancer Society Postdoctoral Fellowship: 07/ /2006 NIH National Research Service Award: 01/ /2003 Boston University School of Medicine Deans Award: 03/2000 Boston University School of Medicine Graduate Student Research Fellowship Award: 08/1998 Henry I. Russek Student Achievement Award, Boston University School of Medicine: 03/1998 Boston University School of Medicine Fellowship, 09/ /2000 Bilkent University Scholarship, 09/ /1995 The Scientific and Technical Research Council of Turkey Scholarship: 09/ /1995 German Language Scholarship from Turkish Language Institute, Summer 1994 European Molecular Biology Laboratory (EMBL) Summer Fellowship in Hamburg, Summer 1993 PUBLICATIONS 1. Gordon WR, Vardar-Ulu D, L'Heureux S, Ashworth T, Malecki MJ, Sanchez-Irizarry C, McArthur DG, Histen G, Mitchell JL, Aster JC, Blacklow SC. Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2. PLoS One Aug 24;4(8):e6613. (PMID: ) 2. Brown JW, Vardar-Ulu Didem, McKnight CJ How to Arm a Supervillin: Using Electrostatics to Design Novel Functionality into Supervillin Headpiece J Mol Biol Aug 14. (PMID: ) 3. Gordon WR, Roy M, Vardar-Ulu D, Garfinkel M, Mansour MR, Aster JC, Blacklow SC Structure of the Notch1 Negative Regulatory Region: Implications for Normal Activation and Pathogenic Signaling in T-ALL Blood. Apr 30;113(18): (2009). Epub 2008 Dec 15 (PMID: ) 4. Gordon WR*, Vardar-Ulu D*, Histen G, Sanchez-Irizarry C, Aster JC, Blacklow SC. Structural basis for autoinhibition of Notch Nat Struct Mol Biol Apr;14(4): (* indicates equal contribution) (PMID: ) 2

3 5. Meng J., Vardar D., Wang,Y., Guo,H., Head J. F., McKnight C. J. High-resolution crystal structures of villin headpiece and mutants with reduced F-actin binding activity. Biochemistry Sep.13;44(36): (PMID: ) 6. Stolt PC, Vardar D., Blacklow SC. The dual-function disabled-1 PTB domain exhibits site independence in binding phosphoinositide and peptide ligands Biochemistry Aug 31;43(34): (PMID: ) 7. Frank BS, Vardar D, Chishti AH, McKnight CJ. The NMR structure of dematin headpiece reveals a dynamic loop that is conformationally altered upon phosphorylation at a distal site J Biol Chem Feb 27;279(9): (PMID: ) 8. Vardar, D., North C. L., Sanchez-Irizarry C., Aster J. C., Blacklow, S.C. Nuclear magnetic resonance structure of a prototype Lin12-Notch repeat module from human Notch1 Biochemistry Jun 17; 42(23): (PMID: ) 9. Frank, B. S., Vardar, D., Buckley, D. A., McKnight, C. J. The Role of Aromatic Residues in the Hydrophobic Core of the Villin Headpiece Subdomain Protein Sci Mar;11(3): (PMID: ) 10. Vardar, D., Chishti, A., Frank, B. S., Luna, E. J., Noegel, A. A., Oh, S. W., Schleicher, M., McKnight, C. J. Villin-type headpiece domains show a wide range of F-actin-binding affinities Cell Motility and the Cytoskeleton, 2002 May; 52(1): 9-21 (PMID: ) 11. Vardar, D., Buckley, D. A., Frank, B. S., McKnight, C. J. NMR structure of an F-actin-binding "headpiece" motif from villin J. Mol. Biol Dec 17;294(5) (PMID: ) 12. Aydinli, A., Timofeev, F. N., Serpenguzel, A., Vardar, D., Gure, M. Visible Photoluminescence from Silicon Oxides and Nitrides Electrochemical Society Proceedings 95-25, p (1996) 13. Aydinli,A., Serpenguzel, A., Vardar, D. Visible Photoluminescence from Low Temperature Deposited Hydrogenated Amorphous Silicon Nitride Solid State Communications, 98, INVITED LECTURES: Hamilton College, Chemistry Department: April 2008 Viewing Biology through the Lens of Biophysical Chemistry: Lin12- Notch Repeats (LNRs) Guest Lecture in Chem361, Wellesley College: December 2007 High-Performance Liquid Chromatography (HPLC) Guest Lecture in CHEM306, Wellesley College: September 2006 Biomolecular Nuclear Magnetic Resonance (NMR) Spectroscopy Academic Career at a Brigham and Women s Postdoctoral Seminar Series, BWH/Harvard Medical School: December 2006 Liberal Arts College: Are you a good fit? Sabanci University, Istanbul, Turkey October 2005 How is Notch Signaling Regulated? Structural and Biochemical Studies on the Negative Regulatory Region of the Notch Receptor Bilkent University, Istanbul, Turkey June 2000 The Structure and Function of Headpiece Domains: A Unique F-Actin Recognition Motif PRESENTATIONS: (* indicates a Wellesley undergraduate student, ** indicates equal contribution) 1. Didem Vardar Ulu, Lauren Choi*, Angie Seo* Interplay between Ca 2+ Binding and Disulfide Bond Formation: Study of Lin-12/Notch Repeats as a Model System Experimental Biology 2010/ ASBMB 2010 Annual Meeting, Anaheim, April Marina Pellon Consunji*; Didem Vardar-Ulu Identification Of Amino Acids That Are Critical For Structural Stability And Functionality Within The Negative Regulatory Region (NRR) Of Notch Proteins YCC/NESACS JCF/GDCh Frühjahrssymposium March 8 15, 2009 Germany and The Northeast Student Chemistry Research Conference (NSCRC), April 25, 2009 Boston, MA 3. Pengying Hao*; Didem Vardar-Ulu Characterization of the Ca 2+ Binding Affinity and Coordination Site of the LIN-12/Notch-Repeat The Biophysical Society's 53 rd Annual Meeting February 28- March Boston, MA 4. Marina Pellon Consunji*; Lucien Celine Montenegro*; Didem Vardar-Ulu Identification Of Amino Acids That Are Critical For Structural Stability And Functionality Within The Negative Regulatory 3

4 Region (NRR) Of Notch Proteins The Biophysical Society's 53 rd Annual Meeting February 28- March Boston, MA 5. Lauren Choi*; Didem Vardar Ulu The Effects of Reduction Potential and Number of Disulfide Bonds on the Correct Folding of Lin-12/Notch Repeats (LNRs) Using Human Notch 1 LNRA as a Model System The Biophysical Society's 53 rd Annual Meeting February 28- March Boston, MA 6. Jessica Lin*; Didem Vardar-Ulu Lin-12/Notch Repeat B: The Effects Of Disulfide Bonding And Hydrophobic Residues On Its Autonomous Folding The Biophysical Society's 53 rd Annual Meeting February 28- March Boston, MA 7. Sharline Madera*; Didem Vardar-Ulu Characterization of protein folding determinants for LIN- 12/Notch-Repeats (LNRs) using Human Notch1 LNRB as a model system ACS National Meeting of the American Chemical Society April , New Orleans, LA 8. Pengying Hao*; Didem Vardar-Ulu Metal Ion Selectivity and Affinity of the LIN-12/Notch-Repeat Joint Meeting of the Biophysical Society 52 nd Annual Meeting and 16 th International Biophysics Congress, February , Long Beach, CA 9. Sharline Madera*; Didem Vardar-Ulu Characterization of protein folding determinants for LIN- 12/Notch-Repeats (LNRs) using Human Notch1 LNR-B as a model system 21 st Annual Symposium of the Protein Society July , Boston, MA 10. **Wendy Ryan Gordon, **Didem Vardar Ulu, Gavin Histen, Cheryll Sanchez-Irizarry, Jon C.Aster, and Stephen C. Blacklow Structural Basis for Autoinhibition of Notch Notch Signaling in Normal and Malignant Hematopoiesis Focus Workshop, Miami Beach, FL, November 15-17, 2006, 11. **Wendy Ryan Gordon, **Didem Vardar Ulu, Cheryll Sanchez-Irizarry, Jon C.Aster, and Stephen C. Blacklow Structural Basis for Autoinhibition of Notch: 2.0 Angstrom crystal structure of the NRR from human Notch 2, The Gordon Conference Diffraction Methods in Structural Biology, Lewiston, Maine; Jul 16-21, Vardar, D., Gordon W., Sanchez-Irizarry, C., Aster J. C., Blacklow S. C. Biochemical and Biophysical Characterization of the Negative Regulatory Region of the Notch Receptors 2005 FEBS Congress and IUBMB Conference, Budapest, Hungary, July Vardar, D., North C. L., Beglova, N., Sanchez-Irizarry, C., Aster J. C., Blacklow S. C NMR Structure of a Prototype LNR Module from hnotch1 17 th Symposium of the Protein Society, Boston, MA, Vardar, D., North C. L., Beglova, N., Sanchez-Irizarry, C., Aster J. C., Blacklow S. C NMR Structure of the first LNR Domain from human Notch1, XXth ICMRBS Meeting, Toronto, August Vardar, D., North C. L., Beglova, N., Sanchez-Irizarry, C., Aster J. C., Blacklow S. C. NMR Structure of the Notch-Unique LIN12A Module, EENC 2002 Meeting, Prague, June Vardar, D., Frank, B. S., and McKnight, C. J. Structure And Function Of Headpiece Domains: An Actin Recognition Motif, Biophysical Society Annual Meeting, Boston, February Vardar, D., Frank, B. S., and McKnight, C. J. Is the Headpiece Really Only an F-actin Binding Domain?, 6 th Annual Henry I Russek Student Achievement Day, Boston University School of Medicine, March Vardar, D., Buckley, D. A., Frank, B. S., and McKnight, C. J. NMR Structure Of The Novel F-Actin Binding Headpiece Motif From Villin, 3 rd European Symposium of the Protein Society, Garmish- Partenkirchen, Germany, September 19-22, Vardar, D., Buckley, D. A., Frank, B. S., and McKnight, C. J. The Functional Implications of the First Headpiece Structure, 3 rd International Conference on Molecular Structural Biology, Vienna, Austria, September 8-12, Vardar, D., Buckley, D. A., Frank, B. S., and McKnight, C. J. The NMR Structure of a Novel F-Actin Binding Motif From Chicken Villin Headpiece. Oral presentation, Boston Area Graduate Student Symposium in Biosciences, University of Massachusetts, April Vardar, D., Frank, B. S., Buckley, D. A., and McKnight, C. J. (1998) NMR Structure of Villin Headpiece and Its Functional Implications, 12 th Symposium of the Protein Society, San Diego, CA 22. Buckley, D. A., Vardar, D. and McKnight, C. J. (1997) A 35-Residue Autonomously Folding Subdomain from Villin Headpiece. PROTEINS Gordon Research Conference, Holderness, NH. 4

5 PROFESSIONAL AFFILIATIONS: American Society Biochemistry and Molecular Biology (ASBMB), The Protein Society, The American Chemical Society (ACS), Sigma Xi, Council on Undergraduate Research (CUR-institutional) PATENTS: Stephen Blacklow, Didem Vardar-Ulu, Wendy Ryan Gordon, Cheryll Sanchez-Irizarry, Jon C. Aster U.S. Patent Application No. 11/803,705 (in progress) Entitled: FUNCTIONAL NEGATIVE REGULATORY DOMAIN SEQUENCES FROM HUMAN NOTCH1 AND 2 AND ISOLATED LNR DOMAINS FROM HUMAN NOTCH1 OTHER PROFESSIONAL ACTIVITIES: Editing and reviewing: Edited chapters for The Molecules of Life: Physical Principles and Cellular Function by Garland Science Taylor & Francis Group, LLC Reviewer for Biochemistry, Biopolymers, BBA-Reviews on Cancer, Science Education Review (SER), Journal of Chemical Education (JCE). Reviewer for Austrian Science Foundation Session Chair for Advances in Teaching Biochemistry at the ACS Meeting August, Boston, MA ASBMB Undergraduate Poster Competition Judge at the ASBMB April 2010 Meeting, Anaheim, CA Biology Scholars Capstone Workshop Attendee, Ft. Collins, CO, May 2009 MIT StarBiochem and StarGenetics Workshop Attendee April 2009 Invited Participant in the NSF-supported AAAS Transforming Undergraduate Education in Biology: Mobilizing the Community for Change Conference Washington, D.C. July 2009 Undergraduate Research mentor for Senior Thesis, Independent Research, Mentoring in Sciences Program, Sophomore Early Research Program students 5

CURRICULUM VITAE. Diana Catalina Canseco, Ph.D

CURRICULUM VITAE. Diana Catalina Canseco, Ph.D CURRICULUM VITAE Diana Catalina, Ph.D. 214.295.0406 dcanseco@dcccd.edu EDUCATION Bachelor of Science (December 1999) Master of Science (Chemistry) (May 2003) Doctor of Philosophy-(Molecular Biology) (May