Cell and Gene Therapy in Transplantation Immunology and Immunogenetics 25. 27. September 2014, Frankfurt am Main Johann Wolfgang Goethe Universität Campus Westend A joint Conference of the 22nd Annual Meeting of the German Society for Immunogenetics (DGI) and Symposium of the LOEWE Center for Cell and Gene Therapy Frankfurt (CGT) Invitation Dear colleagues and friends, On behave of the local organising committee, it is our pleasure to invite you to Frankfurt for the 22 nd Meeting of the German Society for Immunogenetics and Loewe Symposium for Gene Therapy. The theme for this conference is Cell and Gene Therapy in Transplantation Immunology and Immunogenetics. Transplantation immunology has shown in the last decades to be of essential importance to cure malignant hematologic diseases, correct inborn errors and to give new life perspectives for those patients suffering from organ failure. Translational research in understanding humoral and cellular effector mechanism in adaptive and naive immune responses is opening new perspectives in the treatment of a broad spectrum of diseases. The meeting will touch these aspects and will offer the possibility for young scientists to discuss topics with experts in the field. We will have plenary sessions on innate immunity, new trends in stem cell transplantation, gene silencing and cell induction, translational aspects in cells to cure, and new perspectives in organ transplantation. The meeting includes also several educational sessions, to teach and inspire young academics, technicians and students for this interesting field. 2
Invitation General Information The Frankfurt University, Campus Westend is located in the heart of Frankfurt, which offers excellent opera, magnificent theaters, wonderful museums and a large variety of restaurants and pubs. We look forward to welcome you to Frankfurt in September and hope that we will have an inspiring meeting. Venue: Konferenz und Hörsaaltrakt, Johann Wolfgang von Goethe Universität, Campus Westend Grüneburgplatz 1 60323 Frankfurt DGI Loewe CGT Christian Seidl Peter Bader Gerhard Holzberger Hubert Serve Erhard Seifried Organiser: Deutsche Gesellschaft für Immungenetik e.v. (DGI) DGI Congress Presidents Christian Seidl, Frankfurt Gerd Holzberger, Kassel LOEWE CGT Symposium Organisers Peter Bader, Frankfurt Erhard Seifried, Frankfurt Hubert Serve, Frankfurt Congress Organisation Kongress und MesseBüro Lentzsch GmbH Gartenstraße 29 D 61352 Bad Homburg Tel.: 06172/6796 0 Fax: 06172/6796 26 3 4
General Information General Information Scientific Committee DGI Rainer Blasczyk (Hannover) Peter Horn (Essen) Caner Süsal (Heidelberg) Joannis Mytilineos (Ulm) Bernd Spriewald (Erlangen) Gottfried Fischer (Wien) Constanze Schönemann (Berlin) Birgit Gathof (Köln) Harald Schennach (Innsbruck) Monika Lindemann (Essen) Scientific Committee LOEWE CGT Symposium Hubert Serve (Frankfurt) Erhard Seifried (Frankfurt) Peter Bader (Frankfurt) Andreas Zeiher (Frankfurt) Stefanie Dimmeler (Frankfurt) Evelyn Ullrich (Frankfurt) Joachim Koch (Frankfurt) Winfried Wels (Frankfurt) Halvard Bönig (Frankfurt) Local Organising Committee Petra Becker, Frankfurt Halvard Bönig, Frankfurt Angelika Oellerich, Frankfurt Rudolf Richter, Frankfurt Richard Schäfer, Frankfurt Christian Seidl, Frankfurt DGI Board Rainer Blasczyk, Hannover (1. Vorsitzender) Constanze Schönemann, Berlin (2. Vorsitzende) Andrea Dick, München (Schriftführerin) Gerd Holzberger, Kassel (Schatzmeister) Monika Lindemann, Essen (Beisitzerin) Joannis Mytilineos, Ulm (Beisitzer) Sabine Scherer, Heidelberg (Beisitzerin) Congress Office Tanja Knoth Institut für Transfusionsmedizin und Immunhämatologie DRK Blutspendedienst Baden Württemberg Hessen Klinikum der JW Goethe Universität Sandhofstrasse 1 60528 Frankfurt am Main Tel.: 069 6782 444 (Office) Fax: 069 6782 254 e mail: t.knoth@blutspende.de The program has been officially approved by the European Federation for Immunogenetics (EFI) 5 6
Registration Registration Scientific Programme: Registration fee until July 1, 2014 after July 1 and/or on site Members DGI / LOEWE CGT Academic 190, Euro 220, Euro Students/Technologists 100, Euro 140, Euro non Members Academic 210, Euro 230, Euro Students/Technologists 120, Euro 140, Euro Day Ticket (On site registration only) Thursday, September 25 DGI / CGT Members 70, Euro 75, Euro non Members 80, Euro 85, Euro Friday, September 26 DGI / CGT Members 85, Euro 90, Euro non Members 95, Euro 100, Euro Saturday, September 27 DGI / CGT Members 60, Euro 70, Euro non Members 70, Euro 80, Euro Opening Session and Scientific Forum Campus Westend, Thursday, September 25 registered Participants no charge accompanying Persons Euro 20, Conference Dinner Party Frankfurter Gesellschaft Villa Bonn Friday, September 26, 2014 Academic Euro 65, Students/Technologists Euro 50, After Dinner Party, 26.9. Academic Euro 20, Students/Technologists Euro 10, Advanced Training/Education (Online pre registration required) Friday, September 26 Workshop Technologists I / DGI MTA Workshop free of charge for 09.00 10.30 registered participants Workshop Technologists III/ DGI MTA Workshop free of charge for 14.30 15.30 registered participants Forum Technologists/DGI MTA Workshop free of charge for 15.45 16.45 registered participants (max. 20 participants only. Allocation of places will be assigned in accordance with receipt of registrations.) 7 8
Registration and Industrial Exhibition Schedule Registration KONGRESS UND MESSEBÜRO LENTZSCH GmbH Seifgrundstrasse 2, 61348 Bad Homburg Tel.: 06172 6796 0 Fax: 06172 6796 26 e mail: info@kmb lentzsch.de Kongresskonto: Kongress und MesseBüro Lentzsch GmbH Account No. 09 383 6503 Sort Code No. 500 700 24 Deutsche Bank Privat und Geschäftskunden AG IBAN: DE87 5007 0024 0093 8365 03 BIC: DEUTDEDBFRA Insurance Neither the Conference Organisers nor the Conference Secretariat accepts any liability for personal injuries sustained, or for loss or damage to property belonging to conference participants, either during or as a result of the conference. It is strongly recommended that you purchase an insurance policy of your choice as you register for the conference and book your travel. The insurance should be purchased in your country of origin. Cancellation Cancellation of your participation has to be made in writing and sent to KONGRESS UND MESSEBÜRO LENTZSCH GmbH, the Conference Secretariat. For cancellations received before August, 1 st, 2014, no cancellation fee will be charged. After this date, a cancellation fee corresponding to the registration fee will be charged. Industrial Exhibition The Industrial Exhibition will be located in the Foyer of the Tagungs und Hörsaalzentrums im Campus Westend at the Johann Wolfgang Goethe University. For Information on sponsoring or reservation of exhibition boots please contact the Kongress und MesseBüro Lentzsch GmbH. 9 10
Pre Meeting Programme Pre Meeting Programme Tuesday 23 rd of September 2014 Location: Institut für Transfusionsmedizin und Immunhämatologie Universitätsklinikum Frankfurt Campus Niederrad Wednesday 24th of September 2014 Location: Institut für Transfusionsmedizin und Immunhämatologie Universitätsklinikum Frankfurt Campus Niederrad 10:00 17:00 DAkkS/EFI Accreditation Programme ISO training seminar for technical experts 14:00 18:00 DGI Committee Meeting Meeting rooms (tba), Hs 76, University Hospital 14:00 16:00 Organ Transplantation 14:00 16:00 Education and Training 16:00 18:00 Quality Assurance 18:00 19:30 DGI Committee Meeting Meeting Room (tba), Hs 76, University Hospital organised by the Deutsche Akkreditierungsstelle (DAkkS) with support by the EFI Commissioners Region 4 Germany Pre registration is required since participants are entitled to receive a DAkkS notification 17:00 19:30 DGI Board Meeting Meeting room: Conference Stem Cell Transplantation 19:30 22:00 Joint Dinner DGI Board and Commission Members Location : Restaurant Nizza Main 11 12
Scientific Programme Thursday 25th of September 2014 10:00 18:00 Registration Scientific Programme Thursday 25 th of September 2014 15:00 16:45 Plenary Session I (Lecture Hall 2, Ground Floor) New Trends in Stem Cell Transplantation Chairs: Gottfried Fischer, Wien, Hubert Serve, Frankfurt 11:00 Opening of the Industrial Exhibition P1 V1 Histocompatibility in cord blood transplantation Pablo Rubinstein, NYBC, USA Lunch break 13:00 14:30 Opening Session (Lecture Hall 2, Ground Floor) Chairs: Christian Seidl, Frankfurt, Rainer Blasczyk, Hannover Dean of the Medical Faculty LOEWE steering committee DGI congress president Hans Grosse Wilde Award Laudatio Constanze Schönemann, Charite, Berlin The triangle between transplantation, autoimmunity and pregnancy: The view from the distance of an immunologist Ilias Doxiadis, Eurotransplant, Leiden Opening Lecture PO V1 Innate Immunity Clinical perspectives of NK cells for immune therapy Katharine C. Hsu (MSKCC) NY, USA P1 V2 Options for adoptive immune therapies to improve survival in paediatric stem cell transplantation. Peter Bader (Frankfurt) P1 V3 The HLA DPB1 T cell epitope matching algorithm. Clinical and functional aspect of permissive and non permissive alleles. Katharina Fleischhauer (Essen) P1 V4 The NK cell receptor repertoire. Genetics and functional aspect in B ALL and MDS. Markus Uhrberg (Düsseldorf) 16:45 17:15 Coffee Break and Industrial Exhibition 17:15 18:45 Plenary Session II (Lecture Hall 2, Ground Floor) From Gene Silencing to Cell Induction Chairs: Winfried Wels, Frankfurt, Birgit Gathof, Köln P2 V1 MHC universal cells for allogeneic transplantation Rainer Blasczyk (Hannover) P2 V3 Immune modulating of NK cell responses Evelyn Ullrich (Frankfurt) 14:30 15:30 Coffee Break and Industrial Exhibition P2 V4 Pluripotent and somatic stem cells: Diseases modelling and therapeutic applications Peter Horn (Essen) 13 14
Scientific Programme Thursday 25 th of September 2014 19:00 22:00 Opening Session and Scientific Forum (Foyer/Industrial Exhibition) Welcome addresses: Christian Seidl, Frankfurt Hubert Serve, Frankfurt Awards: Chair: Rainer Blasczyk, Hannover (President DGI) Scientific Programme Friday 26th of September 2014 9:00 10:30 Parallel Sessions Abstract Presentation I (Lecture Hall 2, Ground Floor) MTA Workshop I (Lecture Hall 4, 1 st Floor) Educational 10:30 11:15 Coffee Break and Industrial Exhibition Next Generation Award Lecture DGI MTA Awards DGI Best Abstract Award 11:15 12:50 Plenary Session III (Lecture Hall 2, Ground Floor) LOEWE Symposium (Cell and Gene Therapy) Cells to Cure From bench to bed Chairs: NN, Stefanie Dimmeler, Frankfurt P1 V2 The allogeneic role of T cell after stem cell transplantation Alejandro Madrigal (London ), UK Following the opening session, all participants are invited for a Get Together at the Industrial Exhibition at the Forum. P2 V2 Receptor signaling and synapse interaction of NK cells. Joachim Koch (Frankfurt) P3 V4 (Loewe) 10 Minuten (CGT best abstracts) P3 V5 (Loewe) 10 Minuten (CGT best abstracts) P3 V6 (Loewe) 10 Minuten (CGT best abstracts) 12:50 14.00 Lunch Break and Industrial Exhibition 13:00 14:00 Lunch Symposium (2 Sponsoring Exhibitors ) (Lecture Hall 2, EG und Lecture Hall 4, 1st Floor) 15 16
Scientific Programme Friday 26th of September 2014 14:00 15:30 Parallel Sessions Abstract Presentation II (Lecture Hall 2, Ground Floor) LOEWE Symposium on Cell and Gene Therapy A2 O1 Extended Matching criteria for allogeneic stem cell donors The German stem cell registry experience (DRST) Joannis Mytilineos (Ulm) DGI MTA Workshop II (Lecture Hall 4, 1st Floor) Educational 15:45 16:45 DGI MTA Forum (Lecture Hall 4, 1st Floor) Educational (Max. 20 participants only. Pre registration required!) 15:45 16:45 Poster Sessions and Industrial Exhibition (Foyer, Ground Floor and 1st floor) Refreshments and small snacks 15:45 18:00 Poster Session I LOEWE CGT Cell processing and application 15:45 16:30 Poster Session II Molecular Structure and Immune Response 16:45 18:30 DGI General Assembly (Lecture Hall 4, 1st Floor) 19:30 Conference Dinner Gesellschaft für Industrie, Handel und Wissenschaft Villa Bonn Scientific Programme Saturday 27th of September 2014 9:00 10:30 Parallel Sessions Abstract Presentation III (Lecture Hall 2, Ground Floor) 10:00 11:30 Meeting of the German Eurotransplant (ET) Laboratories (Lecture Hall 11) Chairs: Prof. Caner Süsal, Dr. Constanze Schönemann 10:30 11:00 Coffee Break and Industrial Exhibition 11:30 13:15 Plenary Session IV (Lecture Hall 2, Ground Floor) Perspectives in Organ Transplantation Chairs: Helmut Geiger, Frankfurt and Gerhard Opelz, Heidelberg P4 V1 P4 V2 Humoral response: The relevance of cytotoxic and solid phase antibodies for transplant outcome Caner Süsal (Heidelberg) Immune suppressive regiments for the prevention and treatment of humoral rejection Ingeborg Hauser (Frankfurt) P4 V3 Eurotransplant criteria for acceptable and unacceptable antigens Constanze Schönemann (Berlin) P4 V4 Challenges and opportunities in organ transplantation Wolf O. Bechstein (Frankfurt) 13:15 13:30 Concluding remarks Announcement of the next 23 rd DGI Congress 13:30 End of Meeting 17 18
Social Programme Thursday 25th of September 2014 Directions Campus Westend Meeting Venue located at the Hörsaalzentrum Gebäude 4 (Campusplatz) 18:30 Opening Session and Scientific Forum. This scientific forum will take place in the Foyer of the Campus Westend, Industrial Exhibition including a dinner buffet and music presented by the Rhythm and Blues band. Fee registered Participant no charge accompanying Person Euro 20, Venue Hörsaalzentrum Gebäude 4 Friday 26th of September 2014 19:30 Conference Dinner The Conference Dinner will be held at the Villa Bonn of the Frankfurter Gesellschaft für Industrie, Handel und Wissenschaft (Frankfurt Society for Industry, Commerce and Science), providing the opportunity to meet colleagues in a convivial atmosphere enjoy a delightful evening with us! The After dinner party will include DJ and Buffet of Sweets. Fee including After Dinner Party Academic Euro 65, Technologist / Student Euro 50, 22:00 only After Dinner Party, 26.9 Academic Euro 20, Technologist / Student Euro 10, Due to limited number of places, tickets will be assigned according to registration. 19 20
Campus Westend Lecture Hall 2 and Industrial Exhibition Campus Westend Lecture Hall 4 and Parallel Sessions Location Map Hörsaalgebäude 4 (Ground Floor) Plenary Sessions Lecture Hall 2 Industrial Exhibition in the Foyer (Ground Floor) Restaurant and Cafeteria Location Map Hörsaalgebäude 4 (1 st Floor) Plenary Sessions Lecture Hall 2 (Entrance from 1 st Floor level) Parallel Sessions Lecture Hall 4 Industrial Exhibition (DGI) Plenary Sessions (Lecture Hall 2) Abstract Presentations (Lecture Hall 4) Plenary Sessions (Lecture Hall 2) Restaurant /Cafee Sturm und Drang 21 22
Invited Speakers Invited Speakers Prof. Dr. Peter Bader, Director, Section Pediatric Stem Cell Transplantation and Immunology, University of Frankfurt, Germany Prof. Dr. Wolf O. Bechstein, Director, Surgical Clinic, University of Frankfurt, Germany Prof. Dr. Rainer Blasczyk, Director, Institute for Transfusion Medicine, University of Hannover, Germany Prof. Dr. Ilias Doxiadis,, Eurotransplant Foundation, Leiden, The Netherlands Recipient Hans Grosse Wilde Award Prof. Dr. Katharina Fleischhauer, Director, Institute for Cell Therapy Research, University of Essen, Germany Dr. Constanze Schönemann, Director Tissue Typing laboratory, Center for Transfusions Medicine and Cell Therapy, Charité, Berlin, Germany Prof. Dr. Caner Süsal, Director Antibody Diagnostic Laboratory, Collaborative Transplant Study (CTS), University of Heidelberg, Germany Prof. Dr. Markus Uhrberg, Head Natural Immunity Research, Institute for Transplantation Diagnostics and Cell Therapeutics, Düsseldorf, Germany Prof. Dr. Evelyn Ullrich, Head Laboratory of Cellular Immunology, University of Frankfurt, Germany Prof. Dr. Ingeborg Hauser, Section Head Transplantation, Department of Nephrology, University of Frankfurt, Germany Prof. Dr. Peter Horn, Director, Institute for Transfusion Medicine, University Hospital, Essen, Germany Prof. Dr. Catharina Hsu, Chief Physician, Memorial Sloan Kettering Cancer Center, New York, USA Prof. Dr. Joachim Koch, Assistant Professor (Privatdozent) of Biochemistry at the Goethe University Frankfurt, Germany Prof. Dr. Alejandro Madrigal, Director Anthony Nolan Scientific Trust, Royal Free Hospital and University College London, United Kingdom PD Dr.Joannis Mytilineos, Director Department of Transplantion Immunology, University of Ulm, Germany Prof. Dr. Pablo Rubinstein, Director Cord Blood registry, New York Blood Bank, New York, USA 23 24