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Presentation This event, addressed to physicians (specialized in Haematology & Oncology) now in its 9th edition, wants to be an update in oncology and hematology, with an in-depth examination of emerging issues and results of new diagnostic and therapeutic approaches to the treatment of multiple myeloma. Several topics will be discussed, such as young and elderly protocols, biological activities, asymptomatic myeloma and rare diseases, guidelines. This event aims to encourage the development of controlled clinical studies to assess the efficacy and the safety of these new combinations and improve clinical practice in Onco-hematology. The event will include slide presentations and open discussion among all participants. Chairmen Mario Boccadoro University of Turin A.O.U. Città della Salute e della Scienza Turin (Italy) Hermann Einsele Department of Internal Medicine Würzburg University Medical Center Würzburg (Germany) Rotterdam (The Netherlands)

Meeting Venue Splendid Hotel Via Sempione, 12 - Baveno (VB), Italy Tel +39 0323 913992 Promoted by ACCADEMIA NAZIONALE DI MEDICINA Information Tel +39 010 83794225-241 Fax +39 010 83794261 General Manager: Stefania Ledda www.accmed.org Organizing partner FORUM SERVICE Via Martin Piaggio 17/6 16122 Genova With the unconditioned contribution of Gold sponsor Silver sponsor

SECTION OF HEMATOLOGY 9 TH Baveno (Italy), September 24 th -25 th, 2017

Program Sunday, September 24 th 10.30 Registration 11.00 Welcome cocktail 12.00 Welcome and introduction Mario Boccadoro, Herman Einsele, MM YOUNG PROTOCOLS UPFRONT 12.10 Clinical data/clinical issues Michele Cavo,, Bronno van der Holt, Paola Tacchetti 12.50 Clinical data/clinical issues Francesca Gay 13.05 Imaging Elena Zamagni 13.20 Clinical data/clinical issues Hartmut Goldschmidt MM ELDERLY PROTOCOLS UPFRONT 13.35 Transplant in the elderly Christian Straka 13.50 No transplant. Fit and unfit patients Alessandra Larocca 14.05 No transplant. Fit and unfit patients Sonja Zweegman 14.20 Coffee break MM RELAPSED/REFRACTORY PROTOCOLS 14.50 New proteasome inhibitors Martin Gramatzki 15.05 New proteasome inhibitors plus IMIDs 15.20 Nelfinavir and proteasome inhibitors Christopher Driessen 15.35 New IMIDS Evangelos Terpos 15.50 New MoAbs Herman Einsele 16.05 CART-T cells Sophia Danhof SMOLDERING PROTOCOLS 16.20 Smoldering multiple myeloma Annemiek Broijl BIOLOGICAL ACTIVITIES 16.35 MRD and NGS Mark van Duin 16.50 MRD and NGS Paola Omedè 17.05 GEP-based prognostic classification Rowan Kuiper 17.20 Clonal evolution Carolina Terragna OTHER SETTING 17.35 PCL Niels van de Donk 17.50 Conclusions

Monday, September 25 th 9.00 EMN Organization Mario Boccadoro, Herman Einsele, NEW PROPOSALS (internal discussion reserved to speakers and invited discussants) 9.15 Italy Francesca Gay, Elena Zamagni 9.30 Germany Hermann Einsele 9.45 Greece Evangelos Terpos 10.00 Netherlands 10.15 Framework Programme for Research and Innovation 10.30 EMN Data center & organization Rossella Troia 10.45 Coffee break 11.15 Update on guidelines & future proposals Monika Engelhardt, Evangelos Terpos 11.30 EMN 2018 Meeting Giorgio Schirripa 11.45 Conclusions Mario Boccadoro, Hermann Einsele, 12.00 Farewell lunch

Speakers Annemiek Broijl Michele Cavo Sophie Danhof and Medical Oncology Würzburg University Medical Center Würzburg (D) Christopher Driessen Department of Oncology and Hematology Cantonal Hospital St. Gallen St. Gallen (CH) Monika Engelhardt and Oncology University Medical Center Freiburg (D) Francesca Gay Hartmut Goldschmidt Section Multiples Myelom Heidelberg University Hospital Heidelberg (D) Martin Gramatzki Division of Stem Cell Transplantation and Immunotherapy University Hospital Schleswig- Holstein Kiel (D) Rowan Kuiper Alessandra Larocca Paola Omedè Turin (Italy) Giorgio Schirripa Christian Straka Department of Haematology and Oncology Schön Klinik Starnberger See Berg (D) Paola Tacchetti Evangelos Terpos Department of Clinical Therapeutics University of Athens Alexandra General Hospital Athens (GR) Carolina Terragna Rossella Troia Niels van de Donk University Medical Center Utrecht Utrecht (D) Bronno van der Holt HOVON Data Center Clinical Trial Center Mark van Duin Elena Zamagni Sonja Zweegman VU University Medical Center Amsterdam (NL) Invited Discussants Emilie Asselbergs, Mark-Andrea Baertsch Heidelberg (D), Meral Beksac Ankara (TR), Lea Bøjsen Hahn Vejle (DK), Sara Bringhen, Benedetto Bruno, Jo Caers Liège (B), Petra Cornelisse, Francesco Di Raimondo Catania (I), Andreas Günther Kiel (D), Albertha C. Gussinklo Rotterdam (NL), Roman Hajek Ostrava (CZ), Hans Erik Johnsen Aalborg (DK), Sarah Lonergan, Heinz Ludwig Vienna (A), Elias Mai Heidelberg (D), Vittorio Montefusco Milan (I), Pellegrino Musto Rionero in Vulture-PZ (I), Kazem Nasserinejad, Massimo Offidani Ancona (I), Brian Østergaard Vejle (DK), Michael O Dwyer Galway (IRL), Chiara Pautasso, Maria Teresa Petrucci Rome (I), Torben Plesner Vejle (DK), Martin van Vliet, Anders Waage Tronheim (N), Renato Zambello Padua (I)