Magnetic Resonance Techniques in Multiple Sclerosis

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Neuroimaging Research Unit Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute and Vita-Salute San Raffaele University Magnetic Resonance Techniques in Multiple Sclerosis Twentieth Advanced Course SCIENTIFIC PROGRAM CME ACCREDITED COURSE San Raffaele Scientific Institute - Aula Nina e Pinta Via Olgettina, 58-20132 Milan, Italy

ORGANIZING SECRETARIAT Biomedia srl Elisa Motta Via L. Temolo 4 20126 Milano Tel. 02/45498282 - Fax 02/45498199 e-mail: elisa.motta@biomedia.net Biomedia utilizza un Sistema di Gestione Qualità Certificato per progettazione ed erogazione di eventi di formazione residenziale e a distanza e di servizi organizzativi per corsi e convegni

MAGNETIC RESONANCE TECHNIQUES IN MULTIPLE SCLEROSIS Twentieth Advanced Course SCIENTIFIC DIRECTION: Massimo Filippi Maria A. Rocca Giancarlo Comi ORGANIZING SECRETARIAT: Federica Beretta Lucia Zonca FACULTY MEMBERS Wolfgang Brück, Göttingen, Germany Jeffrey A. Cohen, Cleveland, USA Giancarlo Comi, Milan, Italy Nicola De Stefano, Siena, Italy Massimo Filippi, Milan, Italy Achim Gass, Mannheim, Germany Jeroen J. Geurts, Amsterdam, Netherlands Ludwig Kappos, Basel, Switzerland Fred D. Lublin, New York, USA Caterina Mainero, Boston, USA Paolo Preziosa, Milan, Italy Maria A. Rocca, Milan, Italy Stefan Ropele, Graz, Austria Alex Rovira, Barcelona, Spain Bruno Stankoff, Paris, France Martijn van den Heuvel, Utrecht, Netherlands Jens Wuerfel, Basel, Switzerland 1

Program 30 March 2017 9.00-9.15 Welcome, introductory remarks G. Comi 9.15-10.15 Key-note Lecture: 20 years of imaging in MS M. Filippi SESSION I - CHANGING THE DIAGNOSTIC LANDSCAPE Chairs: G. Comi, M. Filippi 10.15-10.45 Defining the clinical course of MS F.D. Lublin 10.45-11.15 Diagnostic criteria for MS J.A. Cohen 11.15-11.45 Coffee break 11.45-12.45 Key-note Lecture: The pathologist s perspective on MS imaging W. Brück 12.45-13.30 Lunch SESSION II - IMPROVED UNDERSTANDING OF DISEASE PATHOPHYSIOLOGY THROUGH THE LENS OF IMAGING Chairs: M.A. Rocca, J.A. Cohen 13.30-14.00 WM: the analysis of myelin content exploiting relaxation and MT effect (MTR, qmt, MWF). Towards a biomarker of myelin damage? S. Ropele 2

Program 14.00-14.30 WM: the analysis of microstructure exploiting diffusion weighted MRI (diffusion tensor, neurite dispersion and density, biophysical models) A. Gass 14.30-15.00 GM imaging: an update J.J. Geurts 15.00-15.30 Afternoon tea SESSION III - IMPROVED UNDERSTANDING OF DISEASE PATHOPHYSIOLOGY THROUGH THE LENS OF IMAGING Chairs: A. Gass, J.J. Geurts 15.30-16.00 Imaging the spinal cord P. Preziosa 16.00-16.30 From network adaptation to network collapse: the role of functional reorganization M.A. Rocca 16.30-17.30 Key-note Lecture: Mapping the structural and functional connectomes: where are we going? M. van den Heuvel 3

Program 31 March 2017 Emerging issues in MS SESSION IV - DIAGNOSIS AND PATHOPHYSIOLOGY Chairs: N. De Stefano, L. Kappos 9.00-9.30 Novel imaging strategies for the clinicians A. Rovira 9.30-10.00 7.0 Tesla and more: what is the future? C. Mainero 10.00-10.45 PET imaging of cellular and molecular abnormalities B. Stankoff 10.45-11.15 Coffee break SESSION V - TREATMENT: FROM CLINICAL TRIALS TO INDIVIDUAL PATIENT Chairs: M. Filippi, C. Mainero 11.15-11.45 Definition of treatment response G. Comi 11.45-12.15 Measuring atrophy: how far is it from clinical use? N. De Stefano 12.15-12.45 Contribution of MRI for an early identification of serious treatment-related side-effects L. Kappos 12.45-13.15 Gadolinium deposition: how will it change patient monitoring? Jens Wuerfel 13.15-14.30 Farewell cocktail 4

General Information REGISTRATION Registration is free and includes admission to scientific sessions, conference materials, coffee breaks, lunch and certificate of attendance. HOW TO REGISTER All participants are kindly recommended to register via the online registration form at www.biomedia.net CONTINUING MEDICAL EDUCATION (ECM only for Italian participants) The event addresses to the disciplines of Neurology, Neurophysiopathology, Neuroradiology and Physical medicine and rehabilitation, Pediatrics. Professional Category: Physicist, physiotherapist, physician, psychologist, Neurophysiology Technician, Radiology Technician. In order to obtain credits, participants must attend the full educational programme (100% of the meeting) and pass the final learning test available on line on the site www.providerecm.it. Provider: Biomedia srl Id: 148 nr. 181718 - nr. credits: 10 CERTIFICATE OF ATTENDANCE A certificate of attendance will be available online after the meeting in MyLogin area on www.biomedia.net. OFFICIAL LANGUAGE English. Simultaneous translation service is not provided. HOTEL ACCOMMODATION In case of accomodation please contact: Biomedia Travel di Biomedia srl Via L. Temolo, 4 20126 Milano Tel.: 02/45498282 - Fax: 02/45498199 - e-mail: biomediatravel@biomedia.net CONGRESS VENUE San Raffaele Scientific Institute - Aula Nina e Pinta Via Olgettina, 58-20132 Milano, Italy HOW TO REACH THE VENUE Motorways: San Raffaele Congress Centre can be reached by all motorways, following the direction "Tangenziale Est" (East ring road) till Cascina Gobba exit. Subway: San Raffaele Congress Centre is connected to Milan by green subway line. The subway stop is Cascina Gobba. Railway: Milano Central Railway Station is connected to San Raffaele Congress Centre by subway (green line). Airports: Malpensa Airport (50 km) and Linate Airport (5km) are connected to San Raffaele Congress Centre by railway, bus or taxi. 5

Magnetic Resonance Techniques in Multiple Sclerosis Twentieth Advanced Course Unrestricted Educational Grant