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September 14th 15th, 2018 Toulouse, France Course Directors Alexandre Avran, Saint Laurent Du Var, France Nicolas Boudou, Toulouse, France Roberto Garbo, Turin, Italy Co-Course Director Yves Louvard, Massy, France Congress Coordinator Gerald S. Werner, Darmstadt, Germany ECC-President George Sianos, Thessaloniki, Greece FINAL PROGRAM www.eurocto2018.com

INDEX Scientific Program: Friday, September 14th, 2018 07 Scientific Program: Saturday, September 15th, 2018 10 Faculty 14 Euro CTO Club 16 Sponsors 21 General Information 22 2 3

COURSE DIRECTORS CO-COURSE DIRECTOR CONGRESS COORDINATOR ECC-PRESIDENT Alexandre Avran, Saint Laurent Du Var, France Nicolas Boudou, Toulouse, France Roberto Garbo, Turin, Italy Yves Louvard, Massy, France Gerald S. Werner, Darmstadt, Germany George Sianos, Thessaloniki, Greece Dear Colleagues, Dear Friends, Thanks to dedicated devices and techniques developed at least over the past ten years the percutaneous coronary intervention of chronic total occlusions has achieved a high success rate with low complications and helped improve our capacity also to treat non-cto lesions. Last year, the major European randomised study the EURO-CTO trial consolidated the indication for CTO revascularisation by PCI. Now we must treat our patients rather by percutaneous intervention than only by medication in order to improve their quality of life. The purpose of this meeting is to enable us to share and discuss our experiences with experts in order to improve CTO PCI. Previous meetings made a great contribution thanks to the live cases presented, but also to their scientific programs and international faculty. Feedback from the attending physicians clearly shows that such focused meetings are of significant value covering the topic in a fashion that is not possible in major interventional meetings with broader interests. This is a great opportunity for us to get together and discuss major issues such as continuous education, techniques and product development, research in the field, as well as to share tips and tricks, among many other topics. This year we are happy to organise the 10th Experts Live CTO Workshop in Toulouse, France, from 14 to 15 September 2018. Why attend such a meeting? The number of studies performed in the field of CTOs has increased considerably, and we shall provide an up-to-date overview of current knowledge. For the fourth time live cases will be part of the program but also live inthe-box, clinical cases. During this expert meeting, we will share more than just scientific data. Tips and tricks, complex cases, devices in research and development will be shared with an international faculty and expert operators. Toulouse is an attractive destination conveniently located in the south of France. We look forward to meeting all of you in Toulouse. Alexandre Avran, Nicolas Boudou, Roberto Garbo Course Directors Yves Louvard Co-Course Director Gerald S. Werner Congress Coordinator George Sianos Euro CTO Club President 4 5

SCIENTIFIC PROGRAM Friday, September 14th, 2018 07:00 Registration 08:00 10:15 08:00 Session 1: CTO Scientific data Chairman: George Sianos, Thessaloniki, Greece Welcome by the Organisers Nicolas Boudou, Toulouse, France; Didier Carrié, Toulouse, France; George Sianos, Thessaloniki, Greece 6 7 08:05 08:45 09:30 10:00 Discussants: Elliot Smith, United Kingdom; Laurent Drogoul, France; Nicolaus Reifart, Germany; Jaroslaw Wójcik, Poland; Didier Carrié, France; Victoria Martin Yuste, France Live Case 1 Kambis Mashayekhi, Bad Krozingen, Germany; Bertrand Ledermann, Nimes, France Live Case 2 Tony de Martini, Downers Grove, USA; Nicolas Boudou, Toulouse, France CTO definitions: Do we need a new consensus? Gerald S. Werner, Darmstadt, Germany Recent publications, key points from this year Carlo Di Mario, Florence, Italy Scores and CTO PCI David Hildick Smith, Brighton, United Kingdom 10:15 Coffee break and exhibition 10:30 12:45 10:30 10:45 10:55 11:00 11:05 Session 2: The Euro CTO Club Chairman: Gerald S. Werner, Darmstadt, Germany Publications from the EuroCTO registry George Sianos, Thessaloniki, Greece EuroCTO trial update, comments, review of the study Victoria Martin Yuste, Saintes, France How to define a success? Anthony Gershlik, Leicester, United Kingdom Discussants: Dimitri Karmpaliotis, USA; Mark Rosenberg, Germany; Luca Grancini, Italy; Artis Kalnins, Latvia; Omer Goktekin, Turkey; Eugenio La Scala, France Live Case 3 Roberto Garbo, Turin, Italy; Sébastien Levesque, Poitiers, France CTO fundamental: Understanding of Wire Structure Etsuo Tsuchikane, Toyohashi, Japan

12:30 Antegrade dissection and reentry: Case selection, tips and tricks to succeed Tony de Martini, Downers Grove, USA 12:45 Lunch and exhibition 13:30 15:45 13:30 Session 3: CTO PCI: Advances in CTO technology Chairman: Carlo Di Mario, Florence, Italy Discussants: Masahisa Yamane, Japan; Gabriele L. Gasparini, Italy; Tim Schäufele, Germany; Luca Grancini, Italy; Fabrice Leroy, France; Rostyslav Prog, Germany Live Case 4 Masahisa Yamane, Sayama City, Japan; Thierry Lefèvre, Massy, France 19:30 Congress Dinner (Meeting Point for Bus Shuttle 19:00 Espaces Vanel); Ground Floor (Elevators) Location: Hôtel-Dieu Saint-Jacques (www.chu-toulouse.fr/-hotel-dieu-saint-jacques) Only a limited number of seats available. We kindly ask you for an early booking. supported by unrestricted educational grants by: 14:00 14:20 14:50 Reverse CART techniques: conventional, directed, extended, assisted Kambis Mashayeki, Bad Krozingen, Germany Live Case 5 Alexandre Avran, Saint Laurent Du Var, France; Carlo Di Mario, Florence, Italy New wires, what we have, what is essential, what is on the horizon Jo Dens, Genk, Belgium 15:15 Guide catheter extensions and CTO PCI Laurent Drogoul, Saint Laurent Du Var, France 15:45 Coffee break and exhibition 16:15 18:45 16:15 Session 4: Associate members session Chairman: Javier Escaned, Madrid, Spain Discussants: Alfredo R. Galassi, Italy; Mauro Carlino, Italy; Laurent Drogoul, France; Valeri Gelev, Bulgaria; Surya Prakasa Rao Vithala, India; Aigars Lismanis, Latvia Live Case 6 Nicolas Boudou, Toulouse, France; Alexander Bufe, Krefeld, Germany Keep safety close to your heart: Impella heart pump 17:15 Rotablator and CTO (Rotablator s birthday: 30 years old in 2018) Nicolaus Reifart, Bad Soden, Germany 18:20 18:25 18:30 J CTO score 3 Pietro Mazzarotto, Lodi, Italy Ipsilateral retrograde CTO PCI Julien Lemoine, Essey les Nancy, France Antegrade Fenestration and Re-Entry Mauro Carlino, Milano, Italy 18:45 End of Scientific Program Educational material intended for European customers under CE Mark 8 9 Safety at heart www.protectedpci.eu

SCIENTIFIC PROGRAM Saturday, September 15th, 2018 08:15 11:00 08:15 10:00 10:10 10:20 10:30 Session 5: Specific CTO situations How to manage: Rapid fire Tips and Tricks Chairman: Thierry Lefèvre, Massy, France Discussants: Tony De Martini, USA; Emmanouil Brilakis, USA; Bernward Lauer, Germany; Priyen Kantilal Shah, India; Alessio La Manna, Italy; Yasushi Asakura, Japan Live Case 7 Gerald S. Werner, Darmstadt, Germany; Laurent Quilliet, Chambray-lès-Tours, France Live Case 8 Kenya Nasu, Toyohashi, Japan; Thomas Hovasse, Massy, France Proximal ambiguity, impenetrable cap Dimitri Karmpaliotis, New York, USA Ostial CTO in RCA, LAD and LCx Alexandre Avran, Saint Laurent Du Var, France Antegrade dissection and haematoma Elliot Smith, London, United Kingdom A stent inside the CTO segment Omer Goktekin, Istanbul, Turkey 12:10 12:20 12:30 Long CTO with tortuosity, calcifications: How to progress inside the CTO segment Lorenzo Azzalini, Milan, Italy CTO and bifurcation: Tips and tricks Gerald S. Werner, Darmstadt, Germany IVUS: When to use, case presentation (How to analyse cap, dissection, lesions) Javier Escaned, Madrid, Spain 13:00 Lunch and exhibition Image Guided Therapy Devices 10:40 10:50 Crossing complex collaterals (Which wires? Microcath?) Masahisa Yamane, Sayama City, Japan Retrograde microcatheter cannot pass the lesion Roberto Garbo, Turin, Italy 11:00 Coffee break and exhibition 11:20 13:00 11:20 Session 6: Case based technical presentation Chairman: Alexander Bufe, Krefeld, Germany Discussants: Etsuo Tsuchikane, Japan; Nicolaus Reifart, Germany; Victoria Martin Yuste, France; Hakim Benamer, France; Nenad Bozinovic, Serbia; Guy Heyndrickx, Belgium Live Case 9 George Sianos, Thessaloniki, Greece; Didier Tchetche, Toulouse, France Overcome uncertainty. Treat confidentally. Philips Eagle Eye Platinum. The only digital IVUS catheter, simplifying treatment of your complex PCI patients. There s always a way to make life better. philips.com/igtdevices 11:50 CTO and LV assist devices Alfredo R. Galassi, Catania, Italy 10 11

Toulouse, France 2018 13:45 16:30 Session 7: From difficult settings to clinical benefit of revascularisation Chairman: Alexandre Avran, Saint Laurent Du Var, France Discussants: Kenya Nasu, Japan; Alexander Lauten, Germany; Carlo Tumscitz, Italy; Carlo Di Mario, Italy; Julien Lemoine, France; Patrick Thomas Siegrist, Switzerland 14:45 Live Case 10 Dimitri Karmpaliotis, New York, USA; Laurent Drogoul, Saint Laurent Du Var, France Live Case 11 Alfredo R. Galassi, Catania, Italy; Daniel Weilenmann, St. Gallen, Switzerland 14:50 A brief review of complications and tips and tricks Yasushi Asakura, Toyohashi, Japan 15:05 CTO in post CABG patients Emmanouil Brilakis, Minneapolis, USA 15:15 Coffee break and exhibition 15:35 Long-term outcome for patients with CTOs Thierry Lefèvre, Massy, France 16:25 Closing remarks George Sianos, Thessaloniki, Greece; Gerald S. Werner, Darmstadt, Germany; Carlo Di Mario, Florence, Italy 16:30 End of Scientific Program 17:00 ECC General Assembly supported by unrestricted educational grants by: 12 13

FACULTY THE EURO CTO CLUB CORDIALLY THANKS THE INVITED SPEAKERS FOR SUPPORTING THE WORKSHOP WITH THEIR KNOWLEDGE AND EXPERTISE: GUESTS FACULTY Manos Brilakis, USA Tony De Martini, USA Dimitri Karmpaliotis, USA Kenya Nasu, Japan Elliot Smith, United Kingdom LIVE OPERATORS Alexandre Avran, France Nicolas Boudou, France Tony De Martini, USA Alredo R. Galassi, Italy Roberto Garbo, Italy Dimitri Karmpaliotis, USA LIVE CASE FACILITATORS Nicolas Boudou, France Alexander Bufe, Germany Carlo Di Mario, Italy Laurent Drogoul, France Thomas Hovasse, France Bertrand Ledermann, France SPEAKERS Alexandre Avran, France Lorenzo Azzalini, Italy Emmanouil Brilakis, USA Mauro Carlino, Italy Tony De Martini, USA Jo Dens, Belgium Carlo Di Mario, Italy Laurent Drogoul, France Javier Escaned, Spain Alfredo R. Galassi, Italy Roberto Garbo, Italy Anthony Gershlick, UK Omer Goktekin, Turkey CHAIRMEN Alexandre Avran, France Alexander Bufe, Germany Carlo Di Mario, Italy Javier Escaned, Spain Etsuo Tsuchikane, Japan Masahisa Yamane, Japan Kambis Mashayekhi, Germany Kenya Nasu, Japan George Sianos, Greece Gerald S. Werner, Germany Masahisa Yamane, Japan Thierry Lefèvre, France Sébastien Levesque, France Laurent Quilliet, France Didier Tchetche, France Daniel Weilenmann, Switzerland David Hildick-Smith, UK Dimitri Karmpaliotis, USA Thierry Lefèvre, France Julien Lemoine, France Victoria Martin Yuste, France Kambis Mashayekhi, Germany Pietro Mazzarotto, Italy Nicolaus Reifart, Germany George Sianos, Greece Elliot Smith, UK Etsuo Tsuchikane, Japan Gerald S. Werner, Germany Masahisa Yamane, Japan Thierry Lefèvre, France George Sianos, Greece Gerald S. Werner, Germany DISCUSSANTS Nenad Bozinovic, Serbia Emmanouil Brilakis, USA Mauro Carlino, Italy Didier Carrié, France Jörg Dalibor, Germany Tony De Martini, USA Carlo Di Mario, Italy Laurent Drogoul, France Alfredo R. Galassi, Italy Gabriele L. Gasparini, Italy Valeri Gelev, Bulgaria Omer Goktekin, Turkey Luca Grancini, Italy Guy Heyndrickx, Belgium Thomas Hovasse, France Artis Kalnins, Latvia Priyen Kantilal Shah, India Dimitri Karmpaliotis, USA Alessio La Manna, Italy Eugenio La Scala, France Bernward Lauer, Germany Alexander Lauten, Germany Julien Lemoine, France Fabrice Leroy, France Aigars Lismanis, Latvia Victoria Martin Yuste, France Kenya Nasu, Japan Rostyslav Prog, Germany Mark Rosenberg, Germany Nicolaus Reifart, Germany Tim Schäufele, Germany Patrick T. Siegrist, Switzerland Elliot Smith, UK Vithala Surya Prakasa Rao, India Etsuo Tsuchikane, Japan Carlo Tumscitz, Italy Jaroslaw Wójcik, Poland Masahisa Yamane, Japan 14

EURO CTO CLUB MEMBERS PRESIDENT George Sianos AHEPA University Hospital Thessaloniki, Greece PAST PRESIDENT Alfredo R. Galassi University of Catania Catania, Italy BOARD Alexandre Avran Arnault Tzanck Institute St Laurent du Var Nice, France TREASURER Hans Bonnier University Hospital Brussels Brussels, Belgium FOUNDING MEMBERS Hans Bonnier, Belgium Heinz Joachim Büttner, Germany Carlo Di Mario, Italy Dariusz Dudek, Poland COORDINATOR MEMBERS Hans Bonnier, Belgium Nicolas Boudou, France Alexander Bufe, Germany Evald Høj Christiansen, Denmark Alfredo R. Galassi, Italy Valeri Gelev, Bulgaria Anthony Gershlick, United Kingdom PRESIDENT ELECT Carlo Di Mario Careggi University Hospital Florence, Italy BOARD Roberto Garbo San Giovanni Bosco Hospital Turin, Italia BOARD Alexander Bufe HELIOS Klinikum Wuppertal, Germany Alfredo R. Galassi, Italy Nicolaus Reifart, Germany George Sianos, Greece Gerald S. Werner, Germany Tevfik Gürmen, Turkey Artis Kalnins, Lithuania Jacques Koolen, Netherlands Victoria Martin Yuste, Spain George Sianos, Greece Daniel Weilenmann, Switzerland Jaroslaw Wójcik, Poland FULL MEMBERS Jürgen Arenz, Germany Alexandre Avran, France Hans Bonnier, Belgium Nicolas Boudou, France Nenad Bozinovic, Serbia Leszek Bryniarski, Poland Alexander Bufe, Germany Heinz Joachim Büttner, Germany Mauro Carlino, Italy Evald Høj Christiansen, Denmark Joerg Dalibor, Germany Jo Dens, Belgium Carlo Di Mario, Italy Laurent Drogoul, France Dariusz Dudek, Poland Simon Elhadad, France Andrejs Erglis, Lithuania Javier Escaned, Spain Andrea Gagnor, Italy Alfredo R. Galassi, Italy Roberto Garbo, Italy Valeri Gelev, Bulgaria Anthony Gershlick, United Kingdom Omer Goktekin, Turkey Luca Grancini, Italy Tevfik Gürmen, Turkey Guy Heyndrickx, Belgium David Hildick-Smith, United Kingdom Karl Isaaz, France Artis Kalnins, Lithuania Jacques Koolen, Netherlands Alessio La Manna, Italy Harald Lapp, Germany Bernward Lauer, Germany Bertrand Ledermann, France Thierry Lefevre, France Fabrice Leroy, France Sébastien Levesque, France Aigar Lismanis, Lithuania Yves Louvard, France Victoria Martin Yuste, Spain Kambis Mashayekhi, Germany Markus Meyer-Gessner, Germany Michael Pieper, Switzerland Rostyslav Prog, Germany Nicolaus Reifart, Germany Mark Rosenberg, Germany Gennaro Sardella, Italy Tim Schäufele, Germany Thomas Schmitz, Germany Antonio Serra, Spain George Sianos, Greece Horst Sievert, Germany James C. Spratt, United Kingdom Sinisa Stojkovic, Serbia Didier Tchetche, France Leif Thuesen, Denmark Carlo Tumscitz, Italy Imre Ungi, Hungary Joachim Weber-Albers, Germany Daniel Weilenmann, Switzerland Gerald S. Werner, Germany Jaroslaw Wójcik, Poland 16 17

ASSOCIATED MEMBERS Ibrahim Akin, Germany Alexander Alexandrov, Bulgaria Ignacio J. Amat-Santos, Spain Iskandar Atmowihardjo, Germany Lorenzo Azzalini, Italy Emanuele Barbato, Belgium Dimitrios Barlagiannis, Germany Hakim Benamer, France Björn Billmann, Germany Ralph Tomas Blank, Germany Josko Bulum, Croatia Giuseppe Caramanno, Italy Tushar Chatterjee, Switzerland Salvatore Colangelo, Italy Stephane Cook, Switzerland Paul Das, United Kingdom Mauro De Benedictis, Italy Fabio Dell Avvocata, Italy Frits de Man, Netherlands Zisis Dimitriadis, Germany Mohaned Egred, United Kingdom Mohammad El Garhy, Germany Mohamed El-Mawardy, Germany Martin Fanderl, Germany Daniele Forlani, Italy Sergey Furkalo, Ukraine Oliver Gaemperli, Switzerland Ali Reza Garachemani, Switzerland Salvatore Garibaldi, Italy Gabriele Luigi Gasparini, Italy Thomas Gehrig, Germany Robert Gerber, United Kingdom Alexander Ghanem, Germany Pietro Giudice, Italy Javier Goicolea, Spain Juan Luis Gutiérrez-Chico, Germany Dirk Hartel, Germany Karl-Eugen Hauptmann, Germany Dobri Hazarbasanov, Bulgaria Barnaba Hejazin, Germany Thomas Hovasse, France Dan Ioanes, Sweden Peiman Jamshidi, Switzerland Marek Jankiewicz, Poland Raban Jeger, Switzerland Alfonso Jurado, Spain Risto Jussila, Finland Tito Kabir, United Kingdom Tomi Kaukonen, Finland Peter Kayaert, Belgium Paul Kelly, United Kingdom Neville Kukreja, United Kingdom Peep Laanmets, Estonia Eugenio La Scala, Italy Artur Lange, Germany Alexander Lauten, Germany Gregor Leibundgut, Switzerland Julien Lemoine, France Maciej Lesiak, Poland Raphy Levy, France Yuri Matchin, Russia Pietro Mazzarotto, Italy Massimo Medda, Italy Ian Menown, Ireland Gabriel Henrique Mesquita, Portugal Mohsen Mohandes, Spain Aris Moschovitis, Switzerland Claus-Heinrich Mueller, Germany Peter Mueller, Switzerland Göran Olivecrona, Sweden Jacopo Oreglia, Italy Sami Ozgul, Turkey Rosario Parisi, Italy Tomasz Pawlowski, Poland Stylianos Pixaras, Germany Marek Radomski, Poland Sudhir Rathore, United Kingdom Gerd Ringwald, Germany Vincent Roolvink, Netherlands Christoph Rubens, Germany Zoltán Ruzsa, Hungary Mohammed Saad, Germany Meruzhan Saghatelyan, Armenia Francesco Scardaci, Italy Joachim Schofer, Germany Ralph Schulze, Germany Gregory Sgueglia, Italy Fabio Sgura, Italy Imhad Sheiban, Italy Mohammad Sherif, Germany Georgios Sitafidis, Greece Nitin Sood, Germany Wojciech Stecko, Poland Julian Strange, United Kingdom Complex, under control Simplify complex interventions Our objective is clear - to simplify even the most complicated procedures with a variety of solutions that overcome common clinical challenges. Gabor Sutsch, Switzerland Aurel Toma, Germany Thor Trovik, Norway Zivile Valuckiene, Lithuania Beatriz Vaquerizo, Spain Ferdinando Varbella, Italy Marios Vlachojannis, Germany Constantin von zur Mühlen, Germany Piotr Wanczura, Poland Hans-Werner Werth, Germany Inge Wijnbergen, Netherlands Join us at the Teleflex Simulator Workshop area 18 19 Teleflex International Main Office: Tel. +353 (0)9 06 46 08 00 Fax +353 (0)14 37 07 73 Orders.intl@teleflex.com

HONORARY MEMBERS Antonio Colombo, Italy Jean Fajadet, France Patrick Serruys, Netherlands We thank the following companies for their support! PLATINUM SPONSOR NON-EUROPEAN AFFILIATED MEMBERS Khaled Shokry, Egypt Khalid Tammam, Saudi Arabia Chris Zambakides, South Africa GOLD SPONSOR NON-EUROPEAN ASSOCIATED MEMBERS Arsis Ahmadieh, Iran Mohamed Metwally, Egypt Ahmed Boghdady, Egypt Shawkat Miro, Iraq Marouane Boukhris, Tunisia Afsaneh Mohammadi, Iran Amr Elsayed Elhadidy, Egypt Bahram Mohebbi, Iran Ata Firouzi, Iran Tarek Rashid, Egypt Afshin Ghofraniha, Iran Mohamed Sobhy, Egypt Hazem Khamis, Egypt Amir Zaky, Egypt Sharaf Eldeen Mahmoud, Egypt SILVER SPONSOR EURO CTO MEMBERSHIP If you would like to become an Euro CTO Club member, please visit the requirements page and check if you are entitled to register: www.eurocto.eu/members_list.aspx BRONZE SPONSOR Biosensors Biotronik Medtronic Siemens FURTHER PARTNER Abiomed AstraZeneca 20 21

GENERAL INFORMATION NOTES 10th Experts Live September 14th 15th, 2018 Toulouse, France Venue Espaces Vanel 1 Allée Chaban Delmas 31500 Toulouse, France Language The official language of the congress is English. No simultaneous translation is available. Certificate of Attendance The Certificate of Attendance will be available on-site at the registration desk. Registration fee 770,00 incl. VAT / per person Reduced rate for fellows: 350,00 incl. VAT / per person (physicians in education/training)* Registration fee includes - Admission to the Scientific Sessions - Catering during the breaks - Certificate of attendance Congress Dinner 70,00 incl. VAT / per person Friday, September 14th, 2018 Online registration: www.eurocto2018.com Congress Organisation wikonect GmbH Hagenauer Straße 53 65203 Wiesbaden, Germany Phone: +49 (0) 611 204 809 14 Fax: +49 (0) 611 204 809 10 email: regina.lichte@wikonect.de www.wikonect.de Scientific Organisation Euro CTO CLUB www.eurocto.eu 22 23