International Conference of translational medicine on pathogenesis and therapy of immunomediated diseases Innate immunity, inflammation and experimental models of human diseases www.translationalimmunology.it PRELIMINARY SCIENTIFIC PROGRAM CONFERENCE VENUE Aula Magna Via Festa del Perdono, 7 Milan UNDER THE AUSPICES OF SIICA SECRETARIAT Rita Repizzi Tel. +39 333 4398196 siica.amministrazione@siica.it www.siica.org Follow us on FACEBOOK ORGANIZING SECRETARIAT Viale G. Matteotti, 7 50121 Florence Italy Ph. +39 055 50351 www.oic.it siica2019@oic.it OIC Srl is a MedTech Trusted Partner
STEERING COMMITTEE Francesco Annunziato Massimo Locati Domenico Mavilio SCIENTIFIC COMMITTEE Francesco Annunziato Flavia Bazzoni Ennio Carbone Marco Cassatella Raffaele De Palma Francesca Di Rosa Armando Gabrielli Francesca Granucci Massimo Locati Enrico Lugli Domenico Mavilio Luis Montaner William Nauseef Luigi Notarangelo Isabella Quinti Angela Santoni Antonio Sica Anna Villa 2
THURSDAY, 16 th MAY 2019 15.00-15.30 OPENING CEREMONY - Welcome and Opening Remarks Massimo Locati, University of Milan and Humanitas Research Hospital, Domenico Mavilio, University of Milan and Humanitas Research Hospital, Angela Santoni, La Sapienza University, Rome, Italy 15.30-17.20 SESSION 1 - AUTOINFLAMMATION AND BEYOND Supported by Society of Leukocyte Biology & Journal of Leukocyte Biology Chairs: Ivona Aksientevich, National Institutes of Health, Bethesda, USA William Nauseef, University of Iowa, Iowa City, USA 15.30-15.50 Anna Villa, CNR and San Raffaele Institute, 15.50-16.00 Selected Abstract 16.00-16.20 Ivona Aksientevich, National Institutes of Health, Bethesda, USA 16.20-16.30 Selected Abstract 16.30-16.50 Marco Gattorno, Istituto Giannina Gaslini, Genoa, Italy 16.50-17.00 Selected Abstract 17.00-17.20 Discussion panel 17.20-17.50 Coffee break 17.50-19.20 SESSION 2 - NEW INSIGHTS IN HAEMATOPOIETIC STEM CELL TRANSPLANT Chairs: Marco A. Cassatella, University of Verona, Italy Luca Castagna, Humanitas Research Hospital, 17.50-18.10 TBD 18.10-18.30 CAR T cells and beyond - Clinics Franco Locatelli, Ospedale Bambin Gesù, Rome, Italy 18.30-18.50 HCMV and Viral infection in HSCT (old and new approaches) Didier Blaise, Centre de Recherche en Cancèrologie de Marseille, Marsiglia, France 18.50-19.10 Discussion panel 3
THURSDAY, 16 th MAY 2019 19.15-20.00 OPENING KEYNOTE LECTURE Chair: Anna Villa, CNR and San Raffaele Institute, (Re)discovering primary immune deficiencies Luigi Notarangelo, National Institutes of Health, Bethesda, USA 20.00 Welcome cocktail for all Delegates 4
THURSDAY, FRIDAY, 17 th 16 MAY th MAY 2019 2019 08.30-09.15 KEYNOTE LECTURE Chair: Luigi Notarangelo, National Institutes of Health, Bethesda, USA Toward a genetic theory of childhood infectious diseases Jean-Laurent Casanova, Rockfeller University, New York, USA 09.20-11.10 SESSION 3 - IMMUNODEFICIENCIES Chairs: Luigi Notarangelo, National Institutes of Health, Bethesda, USA Anna Villa, CNR and San Raffaele Institute, 09.20-09.40 Title TBD Dan Kastner, National Institutes of Health, Bethesda, USA 09.40-09.50 Selected Abstract 09.50-10.10 Human type I interferonopathies: insights into pathogenesis and therapy Yanick J. Crow, University of Edinburgh, Edinburgh, United Kingdom 10.10-10.20 Selected Abstract 10.20-10.40 Anticytokine autoantibodies: what are they doing and what should we do about it? Steve Holland, National Institutes of Health, Bethesda, USA 10.40-10.50 Selected Abstract 10.50-11.10 Discussion panel 11.10-11.30 Coffee break 11.30-13.00 SATELLITE SYMPOSIUM SPONSORED BY BECTON DICKINSON 13.30-14.30 POSTER VIEW 5
FRIDAY, 17 th MAY 2019 14.30-16.20 SESSION 4 - AUTOIMMUNITY Chairs: Francesco Annunziato, University of Florence, Florence, Italy Pierluigi Meroni, Istituto Gaetano Pini, 14.30-14.50 Functional autoantibodiesin systemic sclerosis pathogenesis Armando Gabrielli, University of Ancona, Ancona, Italy 14.50-15.00 Selected Abstract 15.00-15.20 Manipulating regulatory T cell pathways to restore immune tolerance Talal Chatila, Harward University, Boston, USA 15.20-15.30 Selected Abstract 15.30-15.50 Functional adaptation of Foxp3+ regulatory T cells in inflammatory diseases Ciriaco A. Piccirillo, Montreal Diabetes Research Center, Montreal, Quebec, Canada 15.50-16.00 Selected Abstract 16.00-16.20 Discussion panel 16.20-16.50 Coffee break 17.00-17.45 KEYNOTE LECTURE Chair: Angela Santoni, La Sapienza University, Rome, Italy Revisiting interleukin-2: biology and therapeutic advances Abul Abbas, University of California, San Francisco, USA 20.00 Social Dinner and Award ceremony for the best abstracts 6
SATURDAY, 18 th MAY 2019 08.30-09.15 KEYNOTE LECTURE Chair: Domenico Mavilio, University of Milan and Humanitas Research Hospital, Natural killer cells in host defense against viral infection Lewis Lanier, University of California, San Francisco, USA 09.20-11.10 SESSION 5 - IMMUNITY TO INFECTIONS Chairs: Emanuela Marcenaro, University of Genoa, Genoa, Italy Luis Montaner, Wistar Institute, Philadelphia, USA 09.20-09.40 Vaccination, an achievement of civilization Rino Rappuoli, GlaxoSmithKline Vaccines, Siena, Italy 09.40-09.50 Selected Abstract 09.50-10.10 Novel immune-based approaches to cure HIV infection Guido Silvestri, Emory University, Atlanta, USA 10.10-10.20 Selected Abstract 10.20-10.40 A gut feeling: fatal attraction between HIV and Integrin alfa 4 beta 7 Paolo Lusso, National Institutes of Health, Bethesda, USA 10.40-10.50 Selected Abstract 10.50-11.10 Discussion panel 11.10-11.30 Coffee break 11.30-13.00 SATELLITE SYMPOSIUM TBD 13.00-14.30 POSTER VIEW 14.30-15.15 KEYNOTE LECTURE IN MEMORY OF ALESSANDRO MORETTA Chair: Guido Poli, San Raffaele Institute, Innate immunity, inflammation and cancer: double edged swords Alberto Mantovani, Unimed and Humanitas Research Hospital, 7
SATURDAY, 18 th MAY 2019 15.20-17.00 SESSION 6 - TUMOR IMMUNOLOGY Chairs: Angela Santoni, La Sapienza University, Rome, Italy Antonio Sica, University of Piemonte Orientale and Humanitas Research Hospital, 15.20-15.40 Deciphering the immune landscape of human cancer microenviroment : Massimiliano Pagani, University of Milan and Istituto Nazionale Genetica Molecolare, 15.40-15.50 Selected Abstract 15.50-16.10 TBD 16.10-16.20 Selected Abstract 16.20-16.40 TBD 16.40-17.00 Discussion panel 17.00-17.30 Coffee break 17.30-18.00 MEMORIAL AND TRIBUTE TO THE MASTERS Chairs: Domenico Mavilio, University of Milan and Humanitas Research Hospital, Milan Angela Santoni, La Sapienza University, Rome, Italy 17.30-17.40 Vito Pistoia: remembered by Lorenzo Moretta 17.40-17.50 Luigi Varesio: remembered by Antonio Sica A friend who perceived the role of tumor microphysiology in antitumor immunity 17.50-18.00 Alessandro Moretta: A wonderful journey in the land of NK cells with an unforgettable friend Franco Locatelli, Ospedale Bambin Gesù, Rome 8
SATURDAY, 18 th MAY 2019 18.00-18.45 KEYNOTE LECTURE Chair: Lorenzo Moretta, Ospedale Bambin Gesù, Rome, Italy Innate lymphoid cells: from discovery to cancer treatments Eric Vivier, University of Marseille, Marseille, France 18.45-19.00 FAREWELL Massimo Locati, University of Milan and Humanitas Research Hospital, Domenico Mavilio, University of Milan and Humanitas Research Hospital, 9