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ISTITUTO DI EMATOLOGIA L. E A. SERÀGNOLI ALMA MATER STUDIORUM UNIVERSITÀ DI BOLOGNA DIPARTIMENTO DI MEDICINA SPECIALISTICA DIAGNOSTICA E SPERIMENTALE Bologna Royal Hotel Carlton September 16-17, 2014 Presidents: Stefano A. Pileri Co-President: Michele Cavo Honorary President: Sante Tura PROGRAM

Scientific Secretariat Istituto di Ematologia e di Oncologia Medica Lorenzo e Ariosto Seràgnoli Via Massarenti, 9-40138 Bologna, Italy Phone +39 051 6363680 - Fax +39 051 6364037 e-mail: pierluigi.zinzani@unibo.it Organizing Secretariat Studio E.R. Congressi - Triumph Group Via Marconi, 36-40122 Bologna, Italy Phone +39 051 4210559 - Fax +39 051 4210174 e-mail: ercongressi@thetriumph.com www.ercongressi.it Under the Auspices of UNIVERSITÀ DEGLI STUDI DI BOLOGNA REGIONE EMILIA-ROMAGNA AZIENDA OSPEDALIERO-UNIVERSITARIA DI BOLOGNA AIL - ASSOCIAZIONE ITALIANA CONTRO LE LEUCEMIE - LINFOMI E MIELOMA SEZIONE DI BOLOGNA SIE - SOCIETÀ ITALIANA DI EMATOLOGIA Faculty Ranjana Advani Stanford, USA Kirit M. Ardeshna London, UK Angelo Michele Carella Genova, Italy Bruce D. Cheson Washington, USA Bertrand Coiffier Lyon, France Paolo Corradini Milano, Italy Riccardo Dalla Favera New York, USA Andrew Davies Southampton, UK Martin Dreyling Munich, Germany Jehan Dupuis Créteil, France Massimo Federico Modena, Italy Nathan H. Fowler Houston,USA Randy D. Gascoyne Vancouver, Canada Michele Ghielmini Bellinzona, Switzerland Andre Goy Hackensack, USA Wolfgang Hiddemann Munich, Germany Issa Khouri Houston, USA Antonio Pezzutto Berlin, Germany Stefano A. Pileri Bologna, Italy Umberto Ricardi Torino, Italy David A. Roth Cambridge, USA Simon Rule Plymouth, UK Mathias Rummel Giessen, Germany Elena Sabattini Bologna, Italy Gilles A. Salles Lyon, France Reiner Siebert Kiel, Germany Philippe Solal-Celigny Saint-Herblain Cedex, France Michele Spina Aviano, Italy Anna Sureda Barcelona, Spain Umberto Vitolo Torino, Italy Thomas E. Witzig Rochester, USA Anas Younes New York, USA Bologna, Italy 3

Tuesday, September 16, 2014 9.00 a.m. Welcome and Introduction Histopathology and Biology Chairman: S.A. Pileri 9.15 a.m. Histology - S.A. Pileri 9.35 a.m. Microenvironment - R.D. Gascoyne 9.55 a.m. Cytogenetics - R. Siebert 10.15 a.m. Transformed - R. Dalla Favera 10.35 a.m. Discussion 11.00 a.m. Coffee Break Prognosis Chairman: M. Federico 11.15 a.m. The long story of clinical prognostic factors in Lymphoma - P. Solal-Celigny 11.40 a.m. Phenotypic markers - E. Sabattini 11.55 a.m. Prognostic value of FDG-PET - J. Dupuis 12.10 p.m. Discussion 12.30 p.m. Lunch Treatment of early stage and/or low tumor burden Chairman: U. Vitolo 2.00 p.m. Watch and Wait and - K.M. Ardeshna 2.15 p.m. Rituximab role - A.M. Ghielmini 2.30 p.m. Radiotherapy - U. Ricardi 2.45 p.m. Discussion 3.00 p.m. Coffee Break Advanced Stage Front-line therapy Chairmen: B.D. Cheson, B. Coiffier 3.15 p.m. CVP-R - K.M. Ardeshna 3.30 p.m. CHOP-R - W. Hiddemann 3.45 p.m. Bendamustine-R - M. Rummel 4.00 p.m. CHVP-R - G. Salles 4.15 p.m. FMR - P.L. Zinzani 4.30 p.m. Radioimmunotherapy - T. Witzig 4.45 p.m. R 2 - N. Fowler 5.00 p.m. Other new ongoing trials - A. Younes 5.15 p.m. Discussion 4 5

Wednesday, September 17, 2014 8.30 a.m. Lecture Introduction: A.M. Carella New way of rituximab administration - A. Davies Maintenance and Transplanty Chairman: P. Corradini Do we need maintenance after front line therapy? 9.00 a.m. No - B. Cheson 9.15 a.m. Yes - M. Ghielmini Role of transplant: 9.30 a.m. Autologous - A. Sureda 9.45 a.m. Allogeneic - I. Khouri 10.00 a.m. Discussion 12.20 p.m. Anti-CD79/CD22 - R. Advani 12.35 p.m. Ga-101 - B. Coiffier 12.50 p.m. Discussion 1.30 p.m. Conclusions and arrivederci Relapsed/Refractory Status: Old/New Agents Chairmen: M. Spina, P.L. Zinzani 10.20 a.m. Bendamustine - B.D. Cheson 10.35 a.m. Lenalidomide - A. Goy 10.50 a.m. Bortezomib - B. Coiffier 11.05 a.m. Ibrutinib - N. Fowler 11.20 a.m. Idelalisib - A. Younes 11.35 a.m. Copanlisib - M. Dreyling 11.50 a.m. IPI-145: A PI3K delta/gamma inhibitor for indolent NHL - D.A. Roth 12.05 p.m. Zevalin - A. Pezzutto 6 7

GENERAL INFORMATION MEETING VENUE Royal Hotel Carlton Via Montebello, 8-40121 Bologna, Italy Phone +39 051 249361 - Fax +39 051 249724 HOW TO GET THERE By car : From the motorway, turn into the ring road ("Tangenziale") - Exit 7 Fiera and follow direction city center and railway station. By taxi: From the airport about 30 minutes. By bus: Bus 91 and Aerobus from the airport. By train: From the railway station walking distance. OFFICIAL LANGUAGE English. REGISTRATION FEE Euro 250,00 (Italian VAT included) The registration fee includes: Conference kit Partecipation in the scientific sessions Attendance Certificate Coffee breaks Lunch Sildes of the meeting 9

SCIENTIFIC INFORMATION ACKNOWLEDGMENTS SCIENTIFIC COORDINATOR Istituto di Ematologia e di Oncologia Medica Lorenzo e Ariosto Seràgnoli Via Massarenti, 9-40138 Bologna, Italy Phone +39 051 6363680 - Fax +39 051 6364037 E-mail: pierluigi.zinzani@unibo.it SLIDES Slides must be in English. Computer videoprojection will be available in Power Point. Other requirements should be communicated to the Organizing Secretariat as soon as possible. Slides should be handed to the slide center one hour before the beginning of the session and collected at the end. BADGE All registered participants, speakers and exhibitors will be given a badge which they must wear to be admitted to the scientific sessions. ATTENDANCE CERTIFICATE A certificate will be given to all participants at the end of the Meeting. ITALIAN CME CREDITS A request for Italian CME credits have been made as follows: - Provider Studio ER Congressi SRL: ID 828-101106 - no. 9 CME credits for physicians (disciplines: Hematology, Oncology, Radiotherapy, Pathological anatomy and Clinical pathology) and biologists - Educational objective: guidelines-protocols-procedures CELGENE ROCHE MUNDIPHARMA PHARMACEUTICALS BAYER HEALTHCARE PHARMACEUTICALS JANSSEN ITALIA SPECTRUM PHARMACEUTICAL INFINITY PHARMACEUTICALS JANSSEN PHARMACEUTICAL RESEARCH & DEVELOPMENT, L.L.C. EUROPEAN CME CREDITS The program of the has been reviewed and approved for CME accreditation by the European Hematology Association CME Unit. The EHA-CME Unit has approved this educational activity for no. 12 CME credits for physicians and biologists. To request credits, please fill in the questionnaire and return it to the registration desk at the end of the meeting. We remind you that it is necessary to create an EHA-CME account on the EHA website: http://eha-cme.org. CHANGES Parts of the program may be changed without notice. 10

Scientific Secretariat Istituto di Ematologia e di Oncologia Medica Lorenzo e Ariosto Seràgnoli Via Massarenti, 9-40138 Bologna, Italy Phone +39 051 6363680 - Fax +39 051 6364037 e-mail: pierluigi.zinzani@unibo.it Organizing Secretariat Studio E.R. Congressi - Triumph Group Via Marconi, 36-40122 Bologna, Italy Phone +39 051 4210559 - Fax +39 051 4210174 e-mail: ercongressi@thetriumph.com www.ercongressi.it Bologna, Royal Hotel Carlton September 16-17, 2014 struchel.com