Case KG Doc 516 Filed 07/12/18 Page 1 of 2 IN THE UNITED STATES BANKRUPTCY COURT FOR THE DISTRICT OF DELAWARE. Chapter 11. Re: D.I.

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1 Case KG Doc 516 Filed 07/12/18 Page 1 of 2 IN THE UNITED STATES BANKRUPTCY COURT FOR THE DISTRICT OF DELAWARE In re: OREXIGEN THERAPEUTICS, INC., Debtor. 1 Chapter 11 Case No (KG) Re: D.I. 495 NOTICE OF FILING OF REVISED EXHIBIT A TO DEBTOR S TWENTIETH OMNIBUS MOTION FOR ENTRY OF AN ORDER (I) AUTHORIZING THE DEBTOR TO REJECT CERTAIN CONTRACTS AND (II) GRANTING CERTAIN RELATED RELIEF PLEASE TAKE NOTICE that on July 10, 2018, the above-captioned Debtor filed and served the Debtor s Twentieth Omnibus Motion for Entry of an Order (I) Authorizing the Debtor to Reject Certain Contracts and (II) Granting Certain Related Relief (D.I. 481) (the Twentieth Rejection Motion ). PLEASE TAKE FURTHER NOTICE that attached hereto as Exhibit A is a revised list of Contracts 2 that the Debtor seeks to reject pursuant to the Twentieth Rejection Motion (the Revised Contracts List ), modifying the rejection date for certain of the Contracts. PLEASE TAKE FURTHER NOTICE that attached hereto as Exhibit B is a blackline version of the Revised Contracts List as compared with the version of the Contracts list attached as Exhibit A to the Twentieth Rejection Motion. 1 The last four digits of the Debtor s federal tax identification number are The Debtor s mailing address for purposes of this Chapter 11 Case is 3344 North Torrey Pines Court, Suite 200, La Jolla, CA, Motion. Capitalized terms used but not defined herein shall have the meanings ascribed to them in the Rejection

2 Case KG Doc 516 Filed 07/12/18 Page 2 of 2 Dated: July 12, 2018 Wilmington, Delaware MORRIS, NICHOLS, ARSHT & TUNNELL LLP /s/ Tamara K. Mann Robert J. Dehney (No. 3578) Andrew R. Remming (No. 5120) Tamara K. Mann (No. 5643) 1201 N. Market St., 16th Floor P.O. Box 1347 Wilmington, DE Telephone: (302) Facsimile: (302) rdehney@mnat.com aremming@mnat.com tmann@mnat.com - and - Christopher R. Donoho, III (admitted pro hac vice) Christopher R. Bryant (admitted pro hac vice) John D. Beck (admitted pro hac vice) HOGAN LOVELLS US LLP 875 Third Avenue New York, NY Telephone: (212) Facsimile: (212) chris.donoho@hoganlovells.com christopher.bryant@hoganlovells.com john.beck@hoganlovells.com Counsel for Debtor and Debtor in Possession

3 Case KG Doc Filed 07/12/18 Page 1 of 2 EXHIBIT A

4 Case KG Doc Filed 07/12/18 Page 2 of 2 Schedule of Orexigen Therapeutics, Inc. Contracts and Leases Lease (Lessor) / Contract Lease (Lessor) / Contract Lease (Lessor) / Contract Counterparty Counterparty Address Counterparty City, State, Zip Lease / Contract Title Lease / Contract Effective Date Contract / Lease Type AFCO 8885 Rio San Diego Dr Suite 347 San Diego, CA Premium Financing Agreement - Promissory Note 9/18/2017 Executory AON Certificate Tracking P.O. Box 1128 Glenview, IL Certificate of Insurance Request Letter 3/24/2008 Executory Aon Employee Benefits Metropolitan Building James Joyce Street Dublin 1 Ireland Appointment of Aon Employee Benefits 3/9/2016 Executory Aon plc Aon plc 425 Market Suite 2800 San Francisco, CA Employee Equity Plans Consulting Services Agreement 3/25/2016 Executory Aon Risk Services West, Inc. 425 Market Street Suite 2800 San Francisco, CA Engagement Letter (Revised 2/15/2018) Between Aon Risk Services West, Inc. and Orexigen Therapeutics, Inc. 2/15/2018 Executory Botanika Interior Plantscapes P.O. Box San Diego, CA Maintenance contract 5/19/2009 Executory Commercial Security 4241 Ponderosa Ave. Suite D San Diego, CA no contract Cisco Systems, Inc Collections Center Drive Chicago, IL Software as a Service (SaaS) Agreement N/A Executory Cox Communications, LLC; Cox Telcom, LLC 5159 Federal Blvd San Diego, CA Commercial Service Agreement 4/24/2017 Executory Deloitte & Touche LLP 3020 Carrington Mill Blvd. Morrisville, NC Master Services Agreement 10/1/2015 Executory Deloitte & Touche LLP 3020 Carrington Mill Blvd. Morrisville, NC Exhbit A Work Order Number 15 11/15/2016 Executory Marsh Risk & Insurance Services 4445 Eastgate Mall Suite 300 San Diego, CA Certificate of Insurance 4/9/2008 Executory Merrill Lynch Capital 222 North LaSalle Street 16th Floor Chicago, IL Certificate of Insurance 4/9/2008 Executory Original office lease 12/7/2007 Lease Letter re: Lease Agreement dated December 7, 2007 and First Amendment dated September 23, /22/2010 Lease Partial Lease Termination Agreement (Torrey Pines Court, San Diego, ) 2/22/2012 Lease Second Amendment to lease 2/15/2013 Lease Third Amendment to lease 8/17/2015 Lease One Source Telecom 2279 Eagle Glen Pkwy Suite 112- PMB 420 Corona, CA no contract Pitney Bowes Inside Sales Group 27 Waterview Drive Shelton, CT Lease Agreement 11/16/2011 Lease San Diego Gas & Electric P.O. Box San Diego, CA no contract Sharp Business Systems PO Box Billings, MT Sales Order 6/27/2017 Lease Sharp Electronics Corporation dba Sharp Business Systems PO Box Billings, MT Value Lease Agreement 10/1/2017 Lease N. Torrey Pines Road #0982 La Jolla, CA Consulting Agreement 9/1/2010 Lease N. Torrey Pines Road #0982 La Jolla, CA Fourth Amendment to lease 10/25/2016 Lease N. Torrey Pines Road #0982 La Jolla, CA Fifth Amendment to lease 9/11/2017 Lease TPx Communications 515 S. Flower St 45th Floor Los Angeles, CA no contract Verizon Wireless P.O. Box Dallas, TX no contract Wells Fargo Vendor Fin Serv P.O. Box Los Angeles, CA Lease Page 1 of 1

5 Case KG Doc Filed 07/12/18 Page 1 of 2 EXHIBIT B BLACKLINE

6 Case KG Doc Filed 07/12/18 Page 2 of 2 Schedule of Orexigen Therapeutics, Inc. Contracts and Leases Lease (Lessor) / Contract Lease (Lessor) / Contract Lease (Lessor) / Contract Counterparty Counterparty Address Counterparty City, State, Zip Lease / Contract Title Lease / Contract Effective Date Contract / Lease Type AFCO 8885 Rio San Diego Dr Suite 347 San Diego, CA Premium Financing Agreement - Promissory Note 9/18/2017 Executory AON Certificate Tracking P.O. Box 1128 Glenview, IL Certificate of Insurance Request Letter 3/24/2008 Executory Aon Employee Benefits Metropolitan Building James Joyce Street Dublin 1 Ireland Appointment of Aon Employee Benefits 3/9/2016 Executory Aon plc Aon plc 425 Market Suite 2800 San Francisco, CA Employee Equity Plans Consulting Services Agreement 3/25/2016 Executory Aon Risk Services West, Inc. 425 Market Street Suite 2800 San Francisco, CA Engagement Letter (Revised 2/15/2018) Between Aon Risk Services West, Inc. and Orexigen Therapeutics, Inc. 2/15/2018 Executory Botanika Interior Plantscapes P.O. Box San Diego, CA Maintenance contract 5/19/2009 Executory Commercial Security 4241 Ponderosa Ave. Suite D San Diego, CA no contract Cisco Systems, Inc Collections Center Drive Chicago, IL Software as a Service (SaaS) Agreement N/A Executory Cox Communications, LLC; Cox Telcom, LLC 5159 Federal Blvd San Diego, CA Commercial Service Agreement 4/24/2017 Executory Deloitte & Touche LLP 3020 Carrington Mill Blvd. Morrisville, NC Master Services Agreement 10/1/2015 Executory Deloitte & Touche LLP 3020 Carrington Mill Blvd. Morrisville, NC Exhbit A Work Order Number 15 11/15/2016 Executory Marsh Risk & Insurance Services 4445 Eastgate Mall Suite 300 San Diego, CA Certificate of Insurance 4/9/2008 Executory Merrill Lynch Capital 222 North LaSalle Street 16th Floor Chicago, IL Certificate of Insurance 4/9/2008 Executory Original office lease 12/7/2007 Lease Letter re: Lease Agreement dated December 7, 2007 and First Amendment dated September 23, /22/2010 Lease Partial Lease Termination Agreement (Torrey Pines Court, San Diego, ) 2/22/2012 Lease Second Amendment to lease 2/15/2013 Lease Third Amendment to lease 8/17/2015 Lease One Source Telecom 2279 Eagle Glen Pkwy Suite 112- PMB 420 Corona, CA no contract Pitney Bowes Inside Sales Group 27 Waterview Drive Shelton, CT Lease Agreement 11/16/2011 Lease San Diego Gas & Electric P.O. Box San Diego, CA no contract Sharp Business Systems PO Box Billings, MT Sales Order 6/27/2017 Lease Sharp Electronics Corporation dba Sharp Business Systems PO Box Billings, MT Value Lease Agreement 10/1/2017 Lease N. Torrey Pines Road #0982 La Jolla, CA Consulting Agreement 9/1/2010 Lease N. Torrey Pines Road #0982 La Jolla, CA Fourth Amendment to lease 10/25/2016 Lease N. Torrey Pines Road #0982 La Jolla, CA Fifth Amendment to lease 9/11/2017 Lease TPx Communications 515 S. Flower St 45th Floor Los Angeles, CA no contract Verizon Wireless P.O. Box Dallas, TX no contract Wells Fargo Vendor Fin Serv P.O. Box Los Angeles, CA Lease Page 1 of 1